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  Set1- and CIb5-deficiencies disclose the differential regulation of centromere and telomere dynamics in Saccharomyces cerevisiae meiosis

Trelles-Sticken, E., Bonfils, S., Sollier, J., Géli, V., Scherthan, H., & de La Roche Saint-André, C. (2005). Set1- and CIb5-deficiencies disclose the differential regulation of centromere and telomere dynamics in Saccharomyces cerevisiae meiosis. Journal of Cell Science, 118, 4985-4994. doi:10.1242/10.1242/jcs.02612.

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Genre: Zeitschriftenartikel
Alternativer Titel : J. Cell Sci.

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 Urheber:
Trelles-Sticken, Edgar1, Autor
Bonfils, Sandrine, Autor
Sollier, Julie, Autor
Géli, Vincent, Autor
Scherthan, Harry2, Autor           
de La Roche Saint-André, Christophe, Autor
Affiliations:
1Max Planck Society, ou_persistent13              
2Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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Schlagwörter: Set1 C1b5 Meiosis Centromere Telomere Bouquet
 Zusammenfassung: The entry into meiosis is characterized by a lengthy premeiotic S phase and a reorganization of the nuclear architecture. Analysis of centromere and telomere dynamics in wild-type Saccharomyces cerevisiae meiosis suggests that resolution of vegetative centromere and telomere clusters are independent events differently connected to premeiotic S phase. Absence of the B-type cyclin Clb5 or the Set1 histone methyltransferase leads to a delay of premeiotic S phase by separate mechanisms. In clb5{Delta} cells, centromere cluster resolution appears normal, whereas dissolution of the vegetative telomere clusters is impaired and meiosis-specific clustering of telomeres, i.e. bouquet formation, is grossly delayed. In set1{Delta} cells, centromere and telomere redistribution are both impaired and bouquet nuclei are absent, despite proper location of the meiosis-specific telomere protein Ndj1. Thus, centromere and telomere redistribution at the onset of prophase I is differentially regulated, with centromere dispersion occurring independently of premeiotic S phase. The normal kinetics of dissolution of the vegetative telomere clusters in a set1{Delta} mec1-1 mutant suggests the presence of a checkpoint that limits the dispersion of telomeres in absence of Set1.

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Sprache(n): eng - English
 Datum: 2005-10-27
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Identifikatoren: eDoc: 271967
DOI: 10.1242/10.1242/jcs.02612
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Titel: Journal of Cell Science
  Alternativer Titel : J. Cell Sci.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 118 Artikelnummer: - Start- / Endseite: 4985 - 4994 Identifikator: ISSN: 0021-9533