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  A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris

Yan, K.-L., Zhang, X.-J., Wang, Z.-M., Yang, S., Zhang, G.-L., Wang, J., et al. (2006). A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris. The Journal of Investigative Dermatology: Official Journal of the Society for Investigative Dermatology and the European Society for Dermatological Research, 126(5), 1003-1005. doi:10.1038/sj.jid.5700186.

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Genre: Zeitschriftenartikel
Alternativer Titel : J. Invest. Dermatol.

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 Urheber:
Yan, Kai-Lin, Autor
Zhang, Xue-Jun, Autor
Wang, Zhi-Min, Autor
Yang, Sen, Autor
Zhang, Guo-Long, Autor
Wang, Jian, Autor
Xiao, Feng-Li, Autor
Gao, Min, Autor
Cui, Yong, Autor
Chen, Jian-Jun, Autor
Fan, Xing, Autor
Sun, Liang-Dan, Autor
Xia, Qing, Autor
Zhang, Kai-Yue, Autor
Niu, Zhen-Min, Autor
Xu, Shi-Jie, Autor
Tzschach, Andreas1, Autor           
Ropers, Hans-Hilger1, Autor           
Huang, Wei, Autor
Liu, Jian-Jun, Autor
Affiliations:
1Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433549              

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Schlagwörter: MGST2, microsomal glutathione S-transferase 2
 Zusammenfassung: A balanced translocation was recently identified in a German psoriasis patient. One of the breakpoints was mapped immediately upstream of the microsomal glutathione S-transferase 2 (MGST2) gene, suggesting it as a candidate gene. Here, we report the identification of a novel non-synonymous mutation in MGST2 by a comprehensive sequence analysis of MGST2's coding region in Chinese psoriasis samples. We demonstrate that this mutation co-segregated with the disease phenotype within a Chinese family affected with psoriasis vulgaris and is predicted to have an impact on the normal function of MGST2 protein. However, the mutation was absent in 551 additional cases and 384 healthy Chinese controls. While requiring independent confirmation, our results suggest that this rare mutation could play a causal role in a small subset of psoriasis individuals.

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Sprache(n): eng - English
 Datum: 2006-02-23
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 309220
DOI: 10.1038/sj.jid.5700186
 Art des Abschluß: -

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Titel: The Journal of Investigative Dermatology : Official Journal of the Society for Investigative Dermatology and the European Society for Dermatological Research
  Alternativer Titel : J. Invest. Dermatol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 126 (5) Artikelnummer: - Start- / Endseite: 1003 - 1005 Identifikator: ISSN: 0022-202x