Family specific rates of protein evolution

Luz, Hannes; Vingron, Martin

doi:10.1093/bioinformatics/btl073

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Family specific rates of protein evolution

Luz, H., & Vingron, M. (2006). Family specific rates of protein evolution. Bioinformatics, 10, 1166-1171. doi:10.1093/bioinformatics/btl073.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-847B-C Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-847C-A

Genre: Journal Article

Alternative Title : 2

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Luz, Hannes¹, Author
Vingron, Martin², Author

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1Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547
2Gene regulation (Martin Vingron), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479639

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Abstract: Motivation: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework and spot sets of slow and fast evolving proteins. Results: We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.

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Language(s): eng - English

Dates: Date issued: 2006-03-01

Publication Status: Issued

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Identifiers: eDoc: 309552
DOI: 10.1093/bioinformatics/btl073

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Title: Bioinformatics

Alternative Title : 2

Source Genre: Journal

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Pages: - Volume / Issue: 10 Sequence Number: - Start / End Page: 1166 - 1171 Identifier: ISSN: 1367-4803