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  Diabetic endothelin B receptor–deficient rats develop severe hypertension and progressive renal failure

Pfab, T., Thöne-Reineke, C., Theilig, F., Lange, I., Witt, H., Maser-Gluth, C., et al. (2006). Diabetic endothelin B receptor–deficient rats develop severe hypertension and progressive renal failure. Journal of the American Society of Nephrology (Baltimore, MD), 17, 1082-1089. doi:10.1681/ASN.2005080833.

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Genre: Zeitschriftenartikel
Alternativer Titel : J Am Soc Nephrol

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 Urheber:
Pfab, Thiemo, Autor
Thöne-Reineke, Christa, Autor
Theilig, Franziska, Autor
Lange, Ines, Autor
Witt, Henning1, Autor
Maser-Gluth, Christiane, Autor
Bader, Michael, Autor
Stasch, Johannes-Peter, Autor
Ruiz, Patricia1, Autor
Bachmann, Sebastian, Autor
Yanagisawa, Masashi, Autor
Hocher, Berthold, Autor
Affiliations:
1Max Planck Society, ou_persistent13              

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 Zusammenfassung: The endothelin (ET) system has been implicated in the pathogenesis of diabetic nephropathy. The role of the ET-B receptor (ETBR) is still unclear. The effect of ETBR deficiency on the progression of diabetic nephropathy in a streptozotocin model was analyzed in four groups: (1) Homozygous ETBR-deficient (ETBRd) diabetic rats, (2) ETBRd rats, (3) diabetic controls, and (4) wild-type controls. BP and kidney function were measured for 10 wk, followed by biochemical and histologic analysis of the kidneys. The study demonstrates that ETBRd diabetic rats on a normal-sodium diet develop severe hypertension, albuminuria, and a mild reduction of creatinine clearance. The strong BP rise seems not to be caused by activation of the renin-angiotensin-aldosterone system or by suppression of the nitric oxide system. Elevated plasma ET-1, possibly reflecting a reduced ETBR-dependent clearance, seems to cause the severe hypertension via the ETA receptor. The results do not support the hypothesis that a reduction of ETBR activity inhibits the progression of diabetic nephropathy. The study demonstrates for the first time that the combination of diabetes and ETBR deficiency causes severe low-renin hypertension with progressive renal failure.

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Sprache(n): eng - English
 Datum: 2006-04
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 312524
DOI: 10.1681/ASN.2005080833
 Art des Abschluß: -

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Titel: Journal of the American Society of Nephrology (Baltimore, MD)
  Alternativer Titel : J Am Soc Nephrol
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 17 Artikelnummer: - Start- / Endseite: 1082 - 1089 Identifikator: ISSN: 1046-6673