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  A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer

Staub, E., Gröne, J., Mennerich, D., Röpcke, S., Klamann, I., Hinzmann, B., et al. (2006). A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer. Molecular Cancer, 5, 37-37. doi:10.1186/1476-4598-5-37.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-83A9-A Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-83AA-8
Genre: Journal Article
Alternative Title : Mol. Cancer

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 Creators:
Staub, Eike1, Author
Gröne, Jörn, Author
Mennerich, Detlev, Author
Röpcke, Stefan1, Author
Klamann, Irina, Author
Hinzmann, Bernd, Author
Castanos-Velez, Esmeralda, Author
Mann, Benno, Author
Pilarsky, Christian, Author
Brümmendorf, Thomas, Author
Weber, Birgit, Author
Buhr, Heinz-Johannes, Author
Rosenthal, André, Author
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1Max Planck Society, ou_persistent13              

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 Abstract: Background: Cancer development is accompanied by genetic phenomena like deletion and amplification of chromosome parts or alterations of chromatin structure. It is expected that these mechanisms have a strong effect on regional gene expression. Results: We investigated genome-wide gene expression in colorectal carcinoma (CRC) and normal epithelial tissues from 25 patients using oligonucleotide arrays. This allowed us to identify 81 distinct chromosomal islands with aberrant gene expression. Of these, 38 islands show a gain in expression and 43 a loss of expression. In total, 7.892 genes (25.3% of all human genes) are located in aberrantly expressed islands. Many chromosomal regions that are linked to hereditary colorectal cancer show deregulated expression. Also, many known tumor genes localize to chromosomal islands of misregulated expression in CRC. Conclusion: An extensive comparison with published CGH data suggests that chromosomal regions known for frequent deletions in colon cancer tend to show reduced expression. In contrast, regions that are often amplified in colorectal tumors exhibit heterogeneous expression patterns: even show a decrease of mRNA expression. Because for several islands of deregulated expression chromosomal aberrations have never been observed, we speculate that additional mechanisms (like abnormal states of regional chromatin) also have a substantial impact on the formation of co-expression islands in colorectal carcinoma.

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Language(s): eng - English
 Dates: 2006-09-18
 Publication Status: Issued
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 Identifiers: eDoc: 311434
DOI: 10.1186/1476-4598-5-37
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Title: Molecular Cancer
  Alternative Title : Mol. Cancer
Source Genre: Journal
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Pages: - Volume / Issue: 5 Sequence Number: - Start / End Page: 37 - 37 Identifier: ISSN: 1476-4598