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  A novel sporadic Burkitt lymphoma cell line (BLUE-1) with a unique t(6;20)(q15;q11.2) rearrangement

Burmeister, T., MacLeod, R. A. F., Reinhardt, R., Mansmann, V., Loddenkemper, C., Marinets, O., et al. (2006). A novel sporadic Burkitt lymphoma cell line (BLUE-1) with a unique t(6;20)(q15;q11.2) rearrangement. Leukemia Research: Interdisciplinary International, 30(11), 1417-1423. doi:10.1016/j.leukres.2006.03.026.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8347-4 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8348-2
Genre: Journal Article
Alternative Title : Leuk Res

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 Creators:
Burmeister, Thomas, Author
MacLeod, Roderick A. F., Author
Reinhardt, Richard1, Author           
Mansmann, Veit, Author
Loddenkemper, Christoph, Author
Marinets, Olga, Author
Drexler, Hans G., Author
Thiel, Eckhard, Author
Blau, Igor Wolfgang, Author
Affiliations:
1High Throughput Technologies, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433552              

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Free keywords: B-NHL; Immunoglobulin heavy chain; 6q15; 8q24; 14q32; VDJ recombination
 Abstract: We report the establishment and characterization, including HLA-typing, immunophenotypic and molecular cytogenetic analysis, of a novel EBV-negative cell line (BLUE-1) derived from adult relapsed sporadic Burkitt lymphoma. BLUE-1 carries the pathognomonic t(8;14)(q24;q32) effecting MYC/IgHJ fusion and a novel t(6;20)(q15;q11.2) originally present in the patient, analysis of which may facilitate identification of gene target(s) of recurrent 6q rearrangements in B-cell neoplasia. Our findings are discussed in light of the current understanding of endemic and sporadic Burkitt lymphoma. BLUE-1 grows well in culture and should be a useful lymphoma research tool.

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Language(s): eng - English
 Dates: 2006-11-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 305138
DOI: 10.1016/j.leukres.2006.03.026
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Title: Leukemia Research : Interdisciplinary International
  Alternative Title : Leuk Res
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 30 (11) Sequence Number: - Start / End Page: 1417 - 1423 Identifier: ISSN: 0145-2126