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  The Highly Conserved LepA Is a Ribosomal Elongation Factor that Back-Translocates the Ribosome

Qin, Y., Polacek, N., Vesper, O., Staub, E., Einfeldt, E., Wilson, D. N., et al. (2006). The Highly Conserved LepA Is a Ribosomal Elongation Factor that Back-Translocates the Ribosome. Cell, 127(4), 721-733. doi:10.1016/j.cell.2006.09.037.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8336-A Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8337-8
Genre: Journal Article
Alternative Title : Cell

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 Creators:
Qin, Yan1, Author           
Polacek, Norbert, Author
Vesper, Oliver1, Author           
Staub, Eike2, Author
Einfeldt, Edda3, Author           
Wilson, Daniel N.4, Author           
Nierhaus, Knud1, Author           
Affiliations:
1Ribosomes, Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433558              
2Max Planck Society, ou_persistent13              
3Mechanisms of Transcriptional Regulation (Sebastiaan H. Meijsing), Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479641              
4Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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 Abstract: The ribosomal elongation cycle describes a series of reactions prolonging the nascent polypeptide chain by one amino acid and driven by two universal elongation factors termed EF-Tu and EF-G in bacteria. Here we demonstrate that the extremely conserved LepA protein, present in all bacteria and mitochondria, is a third elongation factor required for accurate and efficient protein synthesis. LepA has the unique function of back-translocating posttranslocational ribosomes, and the results suggest that it recognizes ribosomes after a defective translocation reaction and induces a back-translocation, thus giving EF-G a second chance to translocate the tRNAs correctly. We suggest renaming LepA as elongation factor 4 (EF4).

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Language(s): eng - English
 Dates: 2006-11-17
 Publication Status: Issued
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 Identifiers: eDoc: 305649
DOI: 10.1016/j.cell.2006.09.037
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Title: Cell
  Alternative Title : Cell
Source Genre: Journal
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Pages: - Volume / Issue: 127 (4) Sequence Number: - Start / End Page: 721 - 733 Identifier: ISSN: 0092-8674