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  The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse.

Bauer, H., Véron, N., Willert, J., & Herrmann, B. G. (2007). The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse. Genes & Development: A Journal of Celluar and Molecular Biology, 21(1), 143-147. doi:10.1101/gad.414807.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8292-2 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-8293-F
Genre: Journal Article
Alternative Title : Genes Dev

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143.pdf (Any fulltext), 583KB
 
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 Creators:
Bauer, Hermann1, Author           
Véron, Nathalie2, Author
Willert, Jürgen1, Author           
Herrmann, Bernhard G.1, Author           
Affiliations:
1Dept. of Developmental Genetics (Head: Bernhard G. Herrmann), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433548              
2Max Planck Society, ou_persistent13              

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Free keywords: Mouse; transmission ratio distortion; testis; sperm motility; Rho; G proteins
 Abstract: Transmission ratio distortion (TRD), the preferential inheritance of the t haplotype from t/+ males, is caused by the cooperative effect of four t-complex distorters (Tcd1–4) and the single t-complex responder (Tcr) on sperm motility. Here we show that Fgd2, encoding a Rho guanine nucleotide exchange factor, maps to the Tcd2 region. The t allele of Fgd2 is overexpressed in testis compared with wild type. A loss-of-function allele of Fgd2 generated by gene targeting reduces the transmission ratio of the t haplotype th49, directly demonstrating the role of Fgd2 as Distorter. Fgd2 identifies a second Rho G protein signaling pathway promoting TRD.

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Language(s): eng - English
 Dates: 2007-01-01
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 337598
DOI: 10.1101/gad.414807
URI: http://www.genesdev.org/cgi/doi/10.1101/gad.414807
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Title: Genes & Development : A Journal of Celluar and Molecular Biology
  Alternative Title : Genes Dev
Source Genre: Journal
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Pages: - Volume / Issue: 21 (1) Sequence Number: - Start / End Page: 143 - 147 Identifier: ISSN: 0890-9369