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  Arp3 is required during preimplantation development of the mouse embryo

Vauti, F., Prochnow, B. R., Freese, E., Ramasamy, S. K., Ruiz, P., & Arnold, H.-H. (2007). Arp3 is required during preimplantation development of the mouse embryo. FEBS Letters, 581(29), 5691-5697. doi:10.1016/j.febslet.2007.11.031.

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Vauti, Franz, Autor
Prochnow, Blair Raymond, Autor
Freese, Elke, Autor
Ramasamy, Suresh Kumar, Autor
Ruiz, Patricia1, Autor
Arnold, Hans-Henning, Autor
Affiliations:
1Max Planck Society, ou_persistent13              

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Schlagwörter: Arp3-deficient mouse; Embryonic lethality; Abnormal blastocysts
 Zusammenfassung: The role of Arp3 in mouse development was investigated utilizing a gene trap mutation in the Arp3 gene. Heterozygous Arp3WT/GT mice are normal, however, homozygous Arp3GT/GT embryos die at blastocyst stage. Earlier embryonic stages appear unaffected by the mutation, probably due to maternal Arp3 protein. Mutant blastocysts isolated at E3.5 fail to continue development in vitro, lack outgrowth of trophoblast-like cells in culture and express reduced levels of the trophoblast marker Cdx2, while markers for inner cell mass continue to be present. The recessive embryonic lethal phenotype indicates that Arp3 plays a vital role for early mouse development, possibly when trophoblast cells become critical for implantation.

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Sprache(n): eng - English
 Datum: 2007-12-11
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
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Titel: FEBS Letters
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 581 (29) Artikelnummer: - Start- / Endseite: 5691 - 5697 Identifikator: ISSN: 0014-5793