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  Drug-efficacy depends on the inhibitor type and the target position in a metabolic network — a systematic study

Gerber, S., Aßmus, H., Bakker, B., & Klipp, E. (2008). Drug-efficacy depends on the inhibitor type and the target position in a metabolic network — a systematic study. Journal of Theoretical Biology, 252(3), 442-455. doi:10.1016/j.jtbi.2007.09.027.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7FB5-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-7FB6-B
Genre: Journal Article

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 Creators:
Gerber, Susanne, Author
Aßmus, Heike1, Author
Bakker, Barbara, Author
Klipp, Edda2, Author              
Affiliations:
1Max Planck Society, escidoc:persistent13              
2Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, escidoc:1433554              

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Free keywords: Metabolic control analysis, Enzyme inhibition, Flux selectivity, Regulation of biochemical networks
 Abstract: Drug discovery usually focuses on candidate molecules that affect individual reactions with presumed essential functions in the cellular reaction network, especially in the development of diseases. Unfortunately, appropriately designed drugs often fail to show the expected biological effect, since the multitude of interactions in the biochemical reaction network buffers the individual changes or causes significant side effects. We address this problem through a computational approach, which considers the effect of drug application within a generalized biochemical pathway and by studying the effect of changes regarding the type and strength of inhibitors on the reduction of flux. This allows us to systematically search for the appropriate target and for type and concentration of the optimal inhibitor. We propose the flux selectivity as a measure for the discrimination of the effect on different pathways. Since the calculation of the flux selectivity is based on flux control coefficients that are calculated in the non-affected state, it is also a means for predicting the inhibitor efficacy. Furthermore, we will propose how to increase discriminative inhibition in the case of a parasitic disease by using multi-target drugs.

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Language(s): eng - English
 Dates: 2008-06-07
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

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Title: Journal of Theoretical Biology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 252 (3) Sequence Number: - Start / End Page: 442 - 455 Identifier: ISSN: 0022-5193