English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Autoregulation of Th1-mediated inflammation by twist1

Niesner, U., Albrecht, I., Janke, M., Doebis, C., Loddenkemper, C., Lexberg, M. H., et al. (2008). Autoregulation of Th1-mediated inflammation by twist1. Journal of Experimental Medicine, 205(8), 1889-1901. doi:10.1084/jem.20072468.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : J Exp Med

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Niesner, Uwe, Author
Albrecht, Inka, Author
Janke, Marko, Author
Doebis, Cornelia, Author
Loddenkemper, Christoph, Author
Lexberg, Maria H., Author
Eulenburg, Katharina, Author
Kreher, Stephan, Author
Koeck, Juliana, Author
Baumgrass, Ria, Author
Bonhagen, Kerstin, Author
Kamradt, Thomas, Author
Enghard, Philipp, Author
Humrich, Jens Y., Author
Rutz, Sascha, Author
Schulze-Topphoff, Ulf, Author
Aktas, Orhan, Author
Bartfeld, Sina, Author
Radbruch, Helena, Author
Hegazy, Ahmed N., Author
Löhning, Max, AuthorBaumgart, Daniel C., AuthorDuchmann, Rainer, AuthorRudwaleit, Martin, AuthorHäupl, Thomas, AuthorGitelman, Inna, AuthorKrenn, Veit, AuthorGruen, Joachim, AuthorSieper, Jochen, AuthorZeitz, Martin, AuthorWiedenmann, Bertram, AuthorZipp, Frauke, AuthorHamann, Alf, AuthorJanitz, Michal1, Author           Scheffold, Alexander, AuthorBurmester, Gerd R., AuthorChang, Hyun D., AuthorRadbruch, Andreas, Author more..
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

Content

show
hide
Free keywords: -
 Abstract: The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor {kappa}B (NF-{kappa}B)–dependent cytokine expression, is involved in the regulation of inflammation-induced immunopathology. We show that twist1 is expressed by activated T helper (Th) 1 effector memory (EM) cells. Induction of twist1 in Th cells depended on NF-{kappa}B, nuclear factor of activated T cells (NFAT), and interleukin (IL)-12 signaling via signal transducer and activator of transcription (STAT) 4. Expression of twist1 was transient after T cell receptor engagement, and increased upon repeated stimulation of Th1 cells. Imprinting for enhanced twist1 expression was characteristic of repeatedly restimulated EM Th cells, and thus of the pathogenic memory Th cells characteristic of chronic inflammation. Th lymphocytes from the inflamed joint or gut tissue of patients with rheumatic diseases, Crohn's disease or ulcerative colitis expressed high levels of twist1. Expression of twist1 in Th1 lymphocytes limited the expression of the cytokines interferon-{gamma}, IL-2, and tumor necrosis factor-{alpha}, and ameliorated Th1-mediated immunopathology in delayed-type hypersensitivity and antigen-induced arthritis.

Details

show
hide
Language(s): eng - English
 Dates: 2008-08
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Experimental Medicine
  Alternative Title : J Exp Med
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 205 (8) Sequence Number: - Start / End Page: 1889 - 1901 Identifier: ISSN: 0022-1007