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  An integrative approach for analyzing the interplay of genetic and epigenetic changes in tumors

Muradyan, A., Boldt, V., Steininger, A., Stabentheiner, S., Tebel, K., Kreutzberger, J., et al. (2008). An integrative approach for analyzing the interplay of genetic and epigenetic changes in tumors. Archives of Pathology and Laboratory Medicine, 132(10), 1557-1561. Retrieved from http://arpa.allenpress.com/pdfserv/10.1043%2F1543-2165(2008)132%5B1557:AIAFAT%5D2.0.CO%3B2.

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Muradyan, Artur1, Autor           
Boldt, Vivien2, Autor           
Steininger, Anne2, Autor           
Stabentheiner, Stephanie3, Autor
Tebel, Katrin2, Autor           
Kreutzberger, Jürgen1, Autor           
Müller, Ines2, Autor           
Madle, Hannelore3, Autor
Popper, Helmut H., Autor
Ullmann, Reinhard2, Autor           
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              
2Molecular Cytogenetics (Reinhard Ullmann), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479645              
3Max Planck Society, ou_persistent13              

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 Zusammenfassung: The accumulation of chromosomal aberrations is a characteristic feature of tumor development. However, an understanding of tumorigenesis that assumes that changes in DNA copy number always cause equivalent changes in the corresponding RNA and protein levels is an oversimplification and completely ignores the individual genetic and epigenetic context in which an aberration has to be evaluated. We present a brief introduction to various techniques dedicated to the genome-wide analysis of genetic and epigenetic changes, and illustrate how complementary information derived from these various DNA array-based technologies can lead to a better understanding of the consequences of chromosomal aberrations.

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Sprache(n): eng - English
 Datum: 2008-10
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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Titel: Archives of Pathology and Laboratory Medicine
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 132 (10) Artikelnummer: - Start- / Endseite: 1557 - 1561 Identifikator: -