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  Familiality and molecular genetics of attention networks in ADHD

Konrad, K., Dempfle, A., Friedel, S., Heiser, P., Holtkamp, K., Walitza, S., et al. (2010). Familiality and molecular genetics of attention networks in ADHD. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153B(1), 148-158. doi:10.1002/ajmg.b.30967.

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Genre: Journal Article
Alternative Title : Am J Med Genet Part B

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 Creators:
Konrad, Kerstin, Author
Dempfle, Astrid, Author
Friedel, Susann, Author
Heiser, Philip, Author
Holtkamp, Kristian, Author
Walitza, Susanne, Author
Sauer, Sascha1, Author           
Warnke, Andreas, Author
Remschmidt, Helmut, Author
Gilsbach, Susanne, Author
Schäfer, Helmut, Author
Hinney, Anke, Author
Hebebrand, Johannes, Author
Herpertz-Dahlmann, Beate, Author
Affiliations:
1Nutrigenomics and Gene Regulation (Sascha Sauer), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479662              

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Free keywords: Attention deficit/Hyperactivity disorder (ADHD); Endophenotypes; Attention network test; DRD4; DAT1
 Abstract: Indices from a more elementary neuropsychological level might be useful in the search for genes for complex psychiatric disorders, such as ADHD. In this study we investigated systematically whether attentional performance as measured with the Attention Network Test (ANT) is suited for the identification of endophenotypes of ADHD. Attentional performance in affected sib pairs with ADHD (n = 181) was compared to unaffected control siblings (n = 121). Intrafamilial correlation patterns were calculated. In addition, linkage and association analyses were conducted between quantitative scores of attentional functions and dopamine receptor D4 (DRD4) and dopamine transporter (DAT1 or SLC6A3) gene variants. Only the executive attention network was significantly impaired in subjects with ADHD compared to controls (P < 0.05) and showed evidence for familiality in both affected and unaffected families. Linkage analyses revealed the highest LOD score for a severity score based on DSM-IV inattentive symptoms in the DAT1 chromosomal region (LOD score 2.6 at 15 cM). However, a SNP (rs6350) at the DAT1 locus showed a tendency for association with both alerting performance (P = 0.02) and executive attention (P = 0.01) although it did not survive alpha adjustment for multiple testing. No evidence was found for association of any of the investigated phenotypes with the VNTR in the DRD4. Thus, our data suggest that the quantitative behavioral ratings of inattentive symptoms might be more useful when searching for new genes associated with ADHD, however, among the ANT measures the executive attention network seems to be best suited for further endophenotype analyses.

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Language(s): eng - English
 Dates: 2010-01
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
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Title: American Journal of Medical Genetics Part B : Neuropsychiatric Genetics
  Alternative Title : Am J Med Genet Part B
Source Genre: Journal
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Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 153B (1) Sequence Number: - Start / End Page: 148 - 158 Identifier: ISSN: 1552-4841