English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  The COPD genetic association compendium : a comprehensive online database of COPD genetic associations

Castaldi, P. J., Cho, M. H., Cohn, M., Langerman, F., Moran, S., Tarragona, N., et al. (2010). The COPD genetic association compendium: a comprehensive online database of COPD genetic associations. Human Molecular Genetics, 19(3), 526-534. doi:10.1093/hmg/ddp519.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : Hum Mol Genet

Files

show Files
hide Files
:
Castaldi.pdf (Any fulltext), 348KB
Name:
Castaldi.pdf
Description:
-
OA-Status:
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
eDoc_access: PUBLIC
License:
-

Locators

show

Creators

show
hide
 Creators:
Castaldi, P. J., Author
Cho, M. H., Author
Cohn, M., Author
Langerman, F., Author
Moran, S., Author
Tarragona, N., Author
Moukhachen, H., Author
Venugopal, R., Author
Hasimja, D., Author
Kao, E., Author
Wallace, B., Author
Hersh, C. P., Author
Bagade, S., Author
Bertram, L.1, Author           
Silverman, E. K., Author
Trikalinos, T. A., Author
Affiliations:
1Neuropsychiatric Genetics (Lars Bertram), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479655              

Content

show
hide
Free keywords: Adult; Aged; Case-Control Studies; Databases, Genetic; Female; Genetic Predisposition to Disease; Genetics, Population; Glutathione Transferase/genetics; Humans; Male; Middle Aged; Online Systems; Pulmonary Disease, Chronic Obstructive/genetics; Superoxide Dismutase/genetics; Transforming Growth Factor beta1/genetics
 Abstract: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. COPD is thought to arise from the interaction of environmental exposures and genetic susceptibility, and major research efforts are underway to identify genetic determinants of COPD susceptibility. With the exception of SERPINA1, genetic associations with COPD identified by candidate gene studies have been inconsistently replicated, and this literature is difficult to interpret. We conducted a systematic review and meta-analysis of all population-based, case-control candidate gene COPD studies indexed in PubMed before 16 July 2008. We stored our findings in an online database, which serves as an up-to-date compendium of COPD genetic associations and cumulative meta-analysis estimates. On the basis of our systematic review, the vast majority of COPD candidate gene era studies are underpowered to detect genetic effect odds ratios of 1.2-1.5. We identified 27 genetic variants with adequate data for quantitative meta-analysis. Of these variants, four were significantly associated with COPD susceptibility in random effects meta-analysis, the GSTM1 null variant (OR 1.45, CI 1.09-1.92), rs1800470 in TGFB1 (0.73, CI 0.64-0.83), rs1800629 in TNF (OR 1.19, CI 1.01-1.40) and rs1799896 in SOD3 (OR 1.97, CI 1.24-3.13). In summary, most COPD candidate gene era studies are underpowered to detect moderate-sized genetic effects. Quantitative meta-analysis identified four variants in GSTM1, TGFB1, TNF and SOD3 that show statistically significant evidence of association with COPD susceptibility.

Details

show
hide
Language(s): eng - English
 Dates: 2010-02-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 547655
DOI: 10.1093/hmg/ddp519
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Human Molecular Genetics
  Alternative Title : Hum Mol Genet
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 19 (3) Sequence Number: - Start / End Page: 526 - 534 Identifier: ISSN: 1460-2083 (Electronic)