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  Skin and brain age together: The role of hormones in the ageing process.

Makrantonaki, E., Schonknecht, P., Hossini, A. M., Kaiser, E., Katsouli, M. M., Adjaye, J., et al. (2010). Skin and brain age together: The role of hormones in the ageing process. Experimental Gerontology, 45(10), 801-813. doi:10.1016/j.exger.2010.08.005.

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Genre: Journal Article
Alternative Title : Exp Gerontol

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Makrantonaki_sdarticle.pdf (Any fulltext), 652KB
 
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 Creators:
Makrantonaki, E., Author
Schonknecht, P., Author
Hossini, A. M., Author
Kaiser, E., Author
Katsouli, M. M., Author
Adjaye, J.1, Author           
Schroder, J., Author
Zouboulis, C. C., Author
Affiliations:
1Molecular Embryology and Aging (James Adjaye), Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479654              

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Free keywords: Ageing; Sex steroids; Growth factors; Skin; Central nervous system; Alzheimer's disease
 Abstract: The importance of the endocrine environment in the initiation of the ageing process has been elucidated in several in vivo and in vitro studies. Changes in endocrine pathways accompany healthy ageing, these include the growth hormone/insulin-like growth factor-I axis (somatopause) and that of sexual hormones, namely estradiol (menopause), testosterone (andropause), and dehydroepiandrosterone and its sulphate (adrenopause). The clinical significance of these changes is variable and results in morphological and functional alterations of all organ systems including the skin and the central nervous system. Moreover, the pathogenesis of age-associated diseases such as epithelial skin cancer and neurodegenerative diseases has been partly attributed to the lack of hormones. Several studies have been conducted in an attempt to reverse the ageing process and clinical signs by substitution of the serum hormone levels in older individuals, however the benefits of hormone replacement therapy, if any, are still controversial. On the other hand, recent data suggest that skin is a window to the human organism and represents an adequate model for ageing research, also implying the use of skin samples for evaluating the ageing status of the central nervous system.

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Language(s): eng - English
 Dates: 2010-10
 Publication Status: Issued
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Title: Experimental Gerontology
  Alternative Title : Exp Gerontol
Source Genre: Journal
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Pages: - Volume / Issue: 45 (10) Sequence Number: - Start / End Page: 801 - 813 Identifier: ISSN: 0531-5565