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  The German multi-centre study on smoking-related behavior-description of a population-based case-control study

Lindenberg, A., Brinkmeyer, J., Dahmen, N., Gallinat, J., de Millas, W., Mobascher, A., et al. (2011). The German multi-centre study on smoking-related behavior-description of a population-based case-control study. Addict Biol, 16(4), 638-53. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21521423 http://onlinelibrary.wiley.com/store/10.1111/j.1369-1600.2011.00322.x/asset/j.1369-1600.2011.00322.x.pdf?v=1&t=gywopgjf&s=9daa30c5ea68deba1af73af47d2997ea201db8c9.

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Lindenberg, A., Autor
Brinkmeyer, J., Autor
Dahmen, N., Autor
Gallinat, J., Autor
de Millas, W., Autor
Mobascher, A., Autor
Wagner, M., Autor
Schulze-Rauschenbach, S., Autor
Grunder, G., Autor
Spreckelmeyer, K. N., Autor
Clepce, M., Autor
Thurauf, N., Autor
von der Goltz, C., Autor
Kiefer, F., Autor
Steffens, M., Autor
Holler, D., Autor
Diaz-Lacava, A., Autor
Wienker, T.1, Autor           
Winterer, G., Autor
Affiliations:
1Clinical Genetics (Thomas F. Wienker), Dept. of Human Molecular Genetics (Head: Hans-Hilger Ropers), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479643              

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 Zusammenfassung: Tobacco smoking is a major risk factor for most of the diseases leading in mortality. Nicotine dependence (ND), which sustains regular smoking, is now acknowledged to be under substantial genetic control with some environmental contribution. At present, however, genetic studies on ND are mostly conducted in populations that have been poorly characterized with regard to ND-related phenotypes for the simple reason that the respective populations were not primarily collected to study ND. The German multi-centre study 'Genetics of Nicotine Dependence and Neurobiological Phenotypes', which is funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) as part of the Priority Program (Schwerpunktprogramm) SPP1226: 'Nicotine-Molecular and Physiological Effects in CNS', was intended to overcome some of these inherent problems of current genetic studies of ND. The multi-centre study is a population-based case-control study of smokers and never-smokers (n = 2396). The study was unique worldwide because it was the first large-scale genetic study specifically addressing ND with the collection of a wide range of environmental, psychosocial and neurobiological phenotypes. Study design and major population characteristics with emphasis on risk prediction of smoking status were presented in this paper.

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 Datum: 2011
 Publikationsstatus: Erschienen
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Titel: Addict Biol
Genre der Quelle: Zeitschrift
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Seiten: - Band / Heft: 16 (4) Artikelnummer: - Start- / Endseite: 638 - 53 Identifikator: ISSN: 1369-1600 (Electronic) 1355-6215 (Linking)