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  Cocos: Constructing multi-domain protein phylogenies

Homilius, M., Wiedenhoeft, J., Thieme, S., Standfuss, C., Kel, I., & Krause, R. (2011). Cocos: Constructing multi-domain protein phylogenies. PLoS Curr, 3, RRN1240. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21686311.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-790A-1 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-0010-790B-0
Genre: Journal Article

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Homilius, M., Author
Wiedenhoeft, J.1, Author           
Thieme, S.2, Author           
Standfuss, C., Author
Kel, I., Author
Krause, R.1, Author           
Affiliations:
1Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433547              
2Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

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 Abstract: Phylogenies of multi-domain proteins have to incorporate macro-evolutionary events, which dramatically increases the complexity of their construction.We present an application to infer ancestral multi-domain proteins given a species tree and domain phylogenies. As the individual domain phylogenies are often incongruent, we provide diagnostics for the identification and reconciliation of implausible topologies. We implement and extend a suggested algorithmic approach by Behzadi and Vingron (2006).

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 Dates: 2011
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: eDoc: 584786
URI: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21686311
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Title: PLoS Curr
Source Genre: Journal
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Pages: - Volume / Issue: 3 Sequence Number: - Start / End Page: RRN1240 Identifier: ISSN: 2157-3999 (Electronic)