English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Analysis of 4 single-nucleotide polymorphisms in relation to cervical dysplasia and cancer development using a high-throughput ligation-detection reaction procedure

von Keyserling, H., Bergmann, T., Schuetz, M., Schiller, U., Stanke, J., Hoffmann, C., et al. (2011). Analysis of 4 single-nucleotide polymorphisms in relation to cervical dysplasia and cancer development using a high-throughput ligation-detection reaction procedure. International Journal of Gynecological Cancer: Official Journal of the International Gynecological Cancer Society, 21(9), 1664-71. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21897271.

Item is

Files

show Files

Locators

show

Creators

show
hide
 Creators:
von Keyserling, H., Author
Bergmann, T.1, Author           
Schuetz, M., Author
Schiller, U., Author
Stanke, J., Author
Hoffmann, C., Author
Schneider, A., Author
Lehrach, H.1, Author           
Dahl, A.1, Author           
Kaufmann, A. M., Author
Affiliations:
1Dept. of Vertebrate Genomics (Head: Hans Lehrach), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1433550              

Content

show
hide
Free keywords: -
 Abstract: BACKGROUND: Host genetic characteristics and environmental factors may correlate with risk for cervical cancer development. Here we describe a retrospective screening study for single nucleotide polymorphisms (SNPs) in genetic markers TP53, MTHFR, CYP1A1, and CYP2E1 in 749 patients. METHODS: A multiplex ligation-dependent polymerase chain reaction approach was applied. We used archived material from human papillomavirus tests and correlated SNP genotypes to the corresponding clinical data. Semantic integration was used to identify and evaluate the clinical status from electronic health records. RESULTS: An association with cervical cancer and high-grade dysplasia was found for the rare homozygous CC genotype (rs4646903) in CYP1A1 (odds ratio [OR], 8.862). Odds ratios were also significantly elevated for heterozygous MTHFR CT genotype (rs1801133; OR, 1.457). No significant association was found in TP53 (rs1042522) and CYP2E1 (rs3813867). In addition, we found smokers at higher risk (OR, 2.688) and identified pregnancies as a significant risk factor (OR, 1.54). CONCLUSIONS: Our protocol enables a feasible way for further retrospective large sample size evaluation of potential genetic markers. This study revealed genetic associations of a rare SNP genotype with cervical dysplasia in one of the largest patient sample to date that warrants further investigation.

Details

show
hide
Language(s):
 Dates: 2011
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 584771
URI: http://www.ncbi.nlm.nih.gov/pubmed/21897271
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 21 (9) Sequence Number: - Start / End Page: 1664 - 71 Identifier: ISSN: 1525-1438 (Electronic) 1048-891X (Linking)