ausblenden:
Schlagwörter:
Multicatalytic proteinase; Thermoplasma-acidophilum; Projection directions; Crystal-structure; 20s proteasome; Rna-polymerase; Expression; Genes; Archaebacteria; Complex.; Multidisciplinary. Multidisciplinary. Multidisciplinary.
Zusammenfassung:
Large macromolecular assemblies have evolved as a means of compartmentalizing reactions in organisms lacking membrane-bounded compartments. A tricorn-shaped protease was isolated from the archaeon Thermoplasma and was shown to form a multisubunit proteolytic complex. The 120-kilodalton monomer assembled to form a hexameric toroid that could assemble further into a capsid structure. Tricorn protease appeared to act as the core of a proteolytic system; when it interacted with several smaller proteins, it displayed multicatalytic activities. [References: 31]
