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  A critical role for tapasin in the assembly and function of multimeric mhc class i-tap complexes

Ortmann, B., Copeman, J., Lehner, P. J., Sadasivan, B., Herberg, J. A., Grandea, A. G., et al. (1997). A critical role for tapasin in the assembly and function of multimeric mhc class i-tap complexes. Science, 277(5330), 1306-1309. doi:10.1126/science.277.5330.1306.

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Ortmann, B., Autor
Copeman, J., Autor
Lehner, P. J., Autor
Sadasivan, B., Autor
Herberg, J. A., Autor
Grandea, A. G., Autor
Riddell, S. R., Autor
Tampe, R.1, Autor
Spies, T., Autor
Trowsdale, J., Autor
Cresswell, P., Autor
Affiliations:
1External Organizations, ou_persistent22              

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Schlagwörter: Hla class-i; Peptide-binding; Antigen presentation; Cell line; Molecules; Transporters; Expression; Retention; Pathway; Charge.; Multidisciplinary. Multidisciplinary. Multidisciplinary.
 Zusammenfassung: Newly assembled major histocompatibility complex (MHC) class I molecules, together with the endoplasmic reticulum chaperone calreticulin, interact with the transporter associated with antigen processing (TAP) through a molecule called tapasin, The molecular cloning of tapasin revealed it to be a transmembrane glycoprotein encoded by an MHC-linked gene. It is a member of the immunoglobulin superfamily with a probable cytoplasmic endoplasmic reticulum retention signal. Up to four MHC class I-tapasin complexes were found to bind to each TAP molecule. Expression of tapasin in a negative mutant human cell line (220) restored class I-TAP association and normal class I cell surface expression. Tapasin expression also corrected the defective recognition of virus-infected 220 cells by class I-restricted cytotoxic T cells, establishing a critical functional role for tapasin in MHC class I-restricted antigen processing. [References: 38]

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 Datum: 1997-08-29
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 318696
DOI: 10.1126/science.277.5330.1306
 Art des Abschluß: -

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Titel: Science
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 277 (5330) Artikelnummer: - Start- / Endseite: 1306 - 1309 Identifikator: -