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  Arrangement of subunits in 20 s particles consisting of nsf, snaps, and snare complexes

Hohl, T. M., Parlati, F., Wimmer, C., Rothman, J. E., Söllner, T. H., & Engelhardt, H. (1998). Arrangement of subunits in 20 s particles consisting of nsf, snaps, and snare complexes. Molecular Cell, 2(5), 539-548.

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Hohl, T. M., Autor
Parlati, F., Autor
Wimmer, C., Autor
Rothman, J. E., Autor
Söllner, T. H., Autor
Engelhardt, H.1, Autor           
Affiliations:
1External Organizations, ou_persistent22              

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Schlagwörter: Sensitive fusion protein; Synaptosomal-associated protein; Synaptic vesicle docking; Membrane-fusion; Vesicular transport; Alpha-snap; V-snare; Electron-microscopy; Mammalian-cells; Core complex.; Cell & developmental biology.
 Zusammenfassung: The structure of 20 S particles, consisting of NSF, SNAPs, and SNARE complexes, was analyzed by electron microscopy and fluorescence resonance energy transfer. Structural changes associated with the binding of alpha-SNAP and NSF to SNARE complexes define the contribution of each component to the 20 S particle structure. The synaptic SNARE complex forms a 2.5 x 15 nm rod, alpha-SNAP binds laterally to the rod, increasing its width but not its length. NSF binds to one end of the SNAP/SNARE complex; the resulting 20 S particles measure 22 nm in length and vary in width from 6 nm at their narrowest point to 13.5 nm at their widest. The transmembrane domains of VAMP and syntaxin emerge together at the NSF-distal end of 20 S particles, adjacent to the amino terminus of alpha-SNAP. [References: 61]

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 Datum: 1998-11
 Publikationsstatus: Erschienen
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 Identifikatoren: eDoc: 318320
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Titel: Molecular Cell
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 2 (5) Artikelnummer: - Start- / Endseite: 539 - 548 Identifikator: -