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  Genomic structure and refined chromosomal localization of the mouse Ptch2 gene

Fröhlich, L., Liu, Z., Beier, D. R., & Lanske, B. (2002). Genomic structure and refined chromosomal localization of the mouse Ptch2 gene. Cytogenetic and Genome Research, 97(1-2), 106-110.

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Genre: Zeitschriftenartikel
Alternativer Titel : Cytogenet. Genome Res.

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Fröhlich, L.1, Autor           
Liu, Z., Autor
Beier, D. R., Autor
Lanske, B.1, Autor           
Affiliations:
1Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

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 Zusammenfassung: The vertebrate Patched 2 (Ptch2) gene encodes a putative membrane-embedded protein which may have roles in Hedgehog signaling during development and in tumorigenesis. We determined the genomic structure of the mouse Ptch2 gene and show that Ptch2 is composed of 22 exons spanning approximately 18 kb of genomic DNA. The exon-intron boundaries were found to be conserved within the human and mouse Ptch2 genes. Analysis of the 5' flanking region revealed a CpG island, the putative promoter region and the transcriptional start site while a polyadenylation signal as well as a mRNA destabilizing motif were identified in the 3' flanking region. Single-strand conformation polymorphism analysis was used to map mouse Ptch2 to chromosome 4 between the microsatellite markers D4Mit20 and D4Mit334.

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Sprache(n): eng - English
 Datum: 2002
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 34906
ISI: 000178771400019
 Art des Abschluß: -

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Titel: Cytogenetic and Genome Research
  Alternativer Titel : Cytogenet. Genome Res.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 97 (1-2) Artikelnummer: - Start- / Endseite: 106 - 110 Identifikator: ISSN: 1424-8581