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  The Protein Information Resource: an integrated public resource of functional annotation of proteins

Wu, C. H., Huang, H. Z., Arminski, L., Castro-Alvear, J., Chen, Y. X., Hu, Z. Z., et al. (2002). The Protein Information Resource: an integrated public resource of functional annotation of proteins. Nucleic Acids Research, 30(1), 35-37.

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Genre: Journal Article
Alternative Title : Nucleic Acids Res.

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 Creators:
Wu, C. H., Author
Huang, H. Z., Author
Arminski, L., Author
Castro-Alvear, J., Author
Chen, Y. X., Author
Hu, Z. Z., Author
Ledley, R. S., Author
Lewis, K. C., Author
Mewes, H. W.1, Author           
Orcutt, B. C., Author
Suzek, B. E., Author
Tsugita, A., Author
Vinayaka, C. R., Author
Yeh, L. S. L., Author
Zhang, J., Author
Barker, W. C., Author
Affiliations:
1Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              

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 Abstract: The Protein Information Resource (PIR) serves as an integrated public resource of functional annotation of protein data to support genomic/proteomic research and scientific discovery. The PIR, in collaboration with the Munich Information Center for Protein Sequences (MIPS) and the Japan International Protein Information Database (JIPID), produces the PIR- International Protein Sequence Database (PSD), the major annotated protein sequence database in the public domain, containing about 250 000 proteins. To improve protein annotation and the coverage of experimentally validated data, a bibliography submission system is developed for scientists to submit, categorize and retrieve literature information. Comprehensive protein information is available from iProClass, which includes family classification at the superfamily, domain and motif levels, structural and functional features of proteins, as well as cross-references to over 40 biological databases. To provide timely and comprehensive protein data with source attribution, we have introduced a non-redundant reference protein database, PIR-NREF. The database consists of about 800 000 proteins collected from PIR-PSD, SWISS-PROT, TrEMBL, GenPept, RefSeq and PDB, with composite protein names and literature data. To promote database interoperability, we provide XML data distribution and open database schema, and adopt common ontologies. The PIR web site (http://pir.georgetown.edu/) features data mining and sequence analysis tools for information retrieval and functional identification of proteins based on both sequence and annotation information. The PIR databases and other files are also available by FTP (ftp://nbrfa.georgetown.edu/pir_databases).

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Language(s): eng - English
 Dates: 2002-01-01
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 35038
ISI: 000173077100007
 Degree: -

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Title: Nucleic Acids Research
  Alternative Title : Nucleic Acids Res.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 30 (1) Sequence Number: - Start / End Page: 35 - 37 Identifier: ISSN: 0305-1048