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  Structure and function of collagen-derived endostatin inhibitors of angiogenesis

Sasaki, T., Hohenester, E., & Timpl, R. (2002). Structure and function of collagen-derived endostatin inhibitors of angiogenesis. IUBMB Life, 53(2), 77-84.

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Genre: Zeitschriftenartikel
Alternativer Titel : IUBMB Life

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 Urheber:
Sasaki, T.1, Autor           
Hohenester, E., Autor
Timpl, R.1, Autor           
Affiliations:
1Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

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Schlagwörter: angiogenesis inhibitors; cell interactions; collagens; heparin- binding; signal transduction; X-ray structure
 Zusammenfassung: Endostatins are inhibitors of endothelial cell migration and angiogenesis and have been shown to reduce tumor growth in animal models. They are derived from the nontriplehelical C- terminal NC1 domains of collagens XV and XVIII, which are released proteolytically in trimeric form and further converted to monomeric endostatins of about 20 kDa. Both endostatin isoforms share a compact globular fold, but differ in certain binding properties for proteins and cells, as well as in tissue distribution. Differences in activity were found between NC1 domains and endostatins and are related to the oligomerization state. Endostatin effects are not restricted to endothelial cells, but also control renal epithelial cells and neuronal guidance in C. elegans. Cellular receptors are still insufficiently characterized and include for endostatin-XVIII heparan sulfate proteoglycans. Receptor engagement elicits various downstream effects including tyrosine kinase and gene activation. Much remains to be learned, however, about details of the signal transduction cascades and how they interfer with pro-angiogenic factors under physiological conditions and during therapeutic treatment.

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Sprache(n): eng - English
 Datum: 2002-02
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 39336
ISI: 000175450300002
 Art des Abschluß: -

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Titel: IUBMB Life
  Alternativer Titel : IUBMB Life
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 53 (2) Artikelnummer: - Start- / Endseite: 77 - 84 Identifikator: ISSN: 1521-6543