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  Taking a bite: proteasomal protein processing

Rape, M., & Jentsch, S. (2002). Taking a bite: proteasomal protein processing. Nature Cell Biology, 4(5), E113-E116.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-6F4C-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-6F4D-B
Genre: Journal Article
Alternative Title : Nat. Cell Biol.

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 Creators:
Rape, M.1, Author              
Jentsch, S.1, Author              
Affiliations:
1Jentsch, Stefan / Molecular Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society, escidoc:1565156              

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 Abstract: The proteasome is a hollow cylindrical protease that contains active sites concealed within its central cavity. Proteasomes usually completely degrade substrates into small peptides, but in a few cases, degradation can yield biologically active protein fragments. Examples of this are the transcription factors NF-kappaB, Spt23p and Mga2p, which are generated from precursors by proteasomal processing. How distinct protein domains are spared from degradation remains a matter of debate. Here, we discuss several models and suggest a novel mechanism for proteasomal processing.

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Language(s): eng - English
 Dates: 2002-05
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: eDoc: 39320
ISI: 000175325100005
 Degree: -

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Title: Nature Cell Biology
  Alternative Title : Nat. Cell Biol.
Source Genre: Journal
 Creator(s):
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Publ. Info: -
Pages: - Volume / Issue: 4 (5) Sequence Number: - Start / End Page: E113 - E116 Identifier: ISSN: 1465-7392