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  Molecular portrait of human kidney carcinomas: The cDNA microarray profiling of kinases and phosphatases involved in the cell signaling control

Cheburkin, Y. V., Knyazeva, T. G., Peter, S., Knyazev, Y. P., Karelin, M. I., Shkolnik, M. I., et al. (2002). Molecular portrait of human kidney carcinomas: The cDNA microarray profiling of kinases and phosphatases involved in the cell signaling control. Molecular Biology, 36(3), 376-384.

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Genre: Zeitschriftenartikel
Alternativer Titel : Mol. Biol.

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Cheburkin, Y. V.1, 2, Autor           
Knyazeva, T. G.1, Autor           
Peter, S., Autor
Knyazev, Y. P.3, Autor           
Karelin, M. I., Autor
Shkolnik, M. I., Autor
Evtushenko, V. I., Autor
Hanson, K., Autor
Ullrich, A.1, Autor           
Knyazev, P. G.1, Autor           
Affiliations:
1Ullrich, Axel / Molecular Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565172              
2Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              
3External Organizations, ou_persistent22              

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Schlagwörter: molecular oncology; kidney carcinoma; cDNA arrays; expression; clusters; oncogencs; tyrosine kinases; tyrosine phosphatases; dual specificity phosphatases
 Zusammenfassung: Hybridization with cDNA arrays was used to obtain expression profiles of 214 protein-tyrosine kinase, protein-tyrosine phosphatase, dual specificity phosphatase, and other genes for kidney carcinomas (KC) and normal kidney tissues of 34 patients and for seven carcinoma cell lines. Computer analysis revealed three clusters of genes coexpressed in KC. The proliferating- cell gene cluster included MET, VIM, MYC, TOM, PCNA. The neoangiogenesis and blood-cell gene cluster included LCK, HCK, FGR, MAIM, CSFR1, VEGF, FLT1, and KDR. The cluster corresponding to normal, differentiated kidney cells included ERBB2 (HER2) for receptor protein-tyrosine kinase, several phosphatase genes (PTPRE, PTPRB, DUSP9), and EGF. The results suggested that MET, DUSP9, PCNA, TOM, and VIM may serve as diagnostic and prognostic markers in KC. Tubulin and topoisomerase II were assumed to be promising targets for cell proliferation inhibitors in KC.

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Sprache(n): eng - English
 Datum: 2002-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 31383
ISI: 000176468800015
 Art des Abschluß: -

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Titel: Molecular Biology
  Alternativer Titel : Mol. Biol.
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 36 (3) Artikelnummer: - Start- / Endseite: 376 - 384 Identifikator: ISSN: 0026-8933