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  Specific ablation of the nidogen-binding site in the laminin gamma 1 chain interferes with kidney and lung development

Willem, M., Miosge, N., Halfter, W., Smyth, N., Jannetti, I., Burghart, E., et al. (2002). Specific ablation of the nidogen-binding site in the laminin gamma 1 chain interferes with kidney and lung development. Development, 129(11), 2711-2722.

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Genre: Zeitschriftenartikel
Alternativer Titel : Development

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 Urheber:
Willem, M.1, Autor           
Miosge, N., Autor
Halfter, W., Autor
Smyth, N., Autor
Jannetti, I., Autor
Burghart, E., Autor
Timpl, R.2, Autor           
Mayer, U.2, Autor           
Affiliations:
1External Organizations, ou_persistent22              
2Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

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Schlagwörter: basement membrane; Wolffian duct; kidney; lung; morphogenesis; mouse
 Zusammenfassung: Basement membrane assembly is of crucial importance in the development and function of tissues and during embryogenesis. Nidogen 1 was thought to be central in the assembly processes, connecting the networks formed by collagen type IV and laminins, however, targeted inactivation of nidogen I resulted in no obvious phenotype. We have now selectively deleted the sequence coding for the 56 amino acid nidogen-binding site, gamma1III4, within the Lamc1 gene by gene targeting. Here, we show that mice homozygous for the deletion die immediately after birth, showing renal agenesis and impaired lung development. These developmental defects were attributed to locally restricted ruptures in the basement membrane of the elongating Wolffian duct and of alveolar sacculi. These data demonstrate that an interaction between two basement membrane proteins is required for early kidney morphogenesis in vivo.

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Sprache(n): eng - English
 Datum: 2002-06
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 31372
ISI: 000176471600014
 Art des Abschluß: -

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Titel: Development
  Alternativer Titel : Development
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 129 (11) Artikelnummer: - Start- / Endseite: 2711 - 2722 Identifikator: ISSN: 0950-1991