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  The centrosome cycle

Meraldi, P., & Nigg, E. A. (2002). The centrosome cycle. FEBS Letters, 521(1-3), 9-13.

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Genre: Journal Article
Alternative Title : FEBS Lett.

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 Creators:
Meraldi, P.1, Author           
Nigg, E. A.1, Author           
Affiliations:
1Former Research Groups, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565145              

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Free keywords: centrosome duplication; centrosome maturation; centrosome separation; centriole disorientation; protein phosphorylation; proteolysis
 Abstract: The centrosome is the major microtubule-organizing center of animal cells. It influences cell shape and polarity and directs the formation of the bipolar mitotic spindle. Numerical and structural centrosome aberrations have been implicated in disease, notably cancer. In dividing cells, centrosomes need to be duplicated and segregated in synchrony with chromosomes. This centrosome cycle requires a series of structural and functional transitions that are regulated by both phosphorylation and proteolysis. Here we summarize recent information on the regulation of the centrosome cycle and its coordination with the chromosomal cell cycle. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

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Language(s): eng - English
 Dates: 2002-06-19
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 31389
ISI: 000176443600003
 Degree: -

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Title: FEBS Letters
  Alternative Title : FEBS Lett.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: 521 (1-3) Sequence Number: - Start / End Page: 9 - 13 Identifier: ISSN: 0014-5793