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  The murine latent transforming growth factor-β binding protein (Ltbp-1) is alternatively spliced, and maps to a region syntenic to human chromosome 2p21-22

Weiskirchen, R., Moser, M., Günther, K., Weiskirchen, S., & Gressner, A. M. (2003). The murine latent transforming growth factor-β binding protein (Ltbp-1) is alternatively spliced, and maps to a region syntenic to human chromosome 2p21-22. Gene, 308, 43-52.

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Genre: Journal Article
Alternative Title : Gene

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 Creators:
Weiskirchen, R., Author
Moser, M.1, Author           
Günther, K., Author
Weiskirchen, S., Author
Gressner, A. M., Author
Affiliations:
1Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              

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Free keywords: latent transforming growth factor binding protein-1; transforming growth factor-beta 1; whole-genome-radiation panel; T31
 Abstract: The latent transforming growth factor-beta (TGF-beta) binding protein-1 belongs to a family of matrix glycoproteins that is functionally associated with the assembly and secretion of TGF- beta. We have isolated and sequenced a murine similar to 15-kbp contig containing part of Ltbp-1 and used a mouse-hamster radiation hybrid panel to determine its chromosomal localization on distal mouse chromosome 17. This map location is syntenic to human chromosomal subband 2p21-22. Similarly, human LTBP-1 was mapped to 2p21-22 by fluorescence in situ hybridization. Like in humans, the murine Ltbp-1 gene directs the synthesis of two different transcript sizes encoding two alternatively spliced isoforms (Ltbp-1S and Ltbp-1L), which are regulated in a tissue-and stage-dependent manner. Sequence analysis and database searches further reveal that the upstream regions of both isoforms are devoid of TATA and CAAT boxes but contain other putative binding sites for several transcription factors conserved in mouse and human. The utilization of different promoters and their evolutionarily conservation further emphasize the complex regulation of Ltbp-1. (C) 2003 Elsevier Science B.V. All rights reserved.

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Language(s): eng - English
 Dates: 2003-04-10
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 28933
ISI: 000182939500005
 Degree: -

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Title: Gene
  Alternative Title : Gene
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 308 Sequence Number: - Start / End Page: 43 - 52 Identifier: ISSN: 0378-1119