ausblenden:
Schlagwörter:
asymmetric catalysis;
cycloaddition;
disulfonimide;
heterocycles;
organocatalysis
Zusammenfassung:
Bulking up with F: The title reaction proceeds using 1 mol % of the new perfluoroisopropyl chiral disulfonimide catalyst 1 to deliver several 2,6-disubstituted and 2,5,6-trisubstituted dihydropyrones in good yields and with excellent enantiomeric ratios. The utility of this methodology is illustrated with the first enantioselective synthesis of a potent aromatase inhibitor.
