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  Molecular signatures of the three stem cell lineages in Hydra and the emergence of stem cell function at the base of multicellularity

Hemmrich, G., Khalturin, K., Boehm, A.-M., Puchert, M., Anton-Erxleben, F., Wittlieb, J., et al. (2012). Molecular signatures of the three stem cell lineages in Hydra and the emergence of stem cell function at the base of multicellularity. Molecular Biology and Evolution, 29(11), 3267-3280. doi:10.1093/molbev/mss134.

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 Urheber:
Hemmrich, Georg, Autor
Khalturin, Konstantin, Autor
Boehm, Anna-Marei, Autor
Puchert, Malte, Autor
Anton-Erxleben, Friederike, Autor
Wittlieb, Jörg, Autor
Klostermeier, Ulrich C., Autor
Rosenstiel, Philip, Autor
Oberg, Hans-Heinrich, Autor
Domazet-Lošo, Tomislav1, Autor           
Sugimoto, Toshimi, Autor
Niwa, Hitoshi, Autor
Bosch, Thomas C.G., Autor
Affiliations:
1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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Schlagwörter: aging; adult stem cell; self-renewal; differentiation; evolution
 Zusammenfassung: How distinct stem cell populations originate and whether there is a clear stem cell “genetic signature” remain poorly understood. Understanding the evolution of stem cells requires molecular profiling of stem cells in an animal at a basal phylogenetic position. In this study, using transgenic Hydra polyps, we reveal for each of the three stem cell populations a specific signature set of transcriptions factors and of genes playing key roles in cell type-specific function and interlineage communication. Our data show that principal functions of stem cell genes, such as maintenance of stemness and control of stem cell self-renewal and differentiation, arose very early in metazoan evolution. They are corroborating the view that stem cell types shared common, multifunctional ancestors, which achieved complexity through a stepwise segregation of function in daughter cells.

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Sprache(n): eng - English
 Datum: 2012-05-162012-11-11
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1093/molbev/mss134
Anderer: 2963/S 39308
 Art des Abschluß: -

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Titel: Molecular Biology and Evolution
  Andere : Mol. Biol. Evol.
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Chicago, Ill. : University of Chicago Press
Seiten: - Band / Heft: 29 (11) Artikelnummer: - Start- / Endseite: 3267 - 3280 Identifikator: ISSN: 0737-4038 (print)
ISSN: 1537-1719 (online)
CoNE: https://pure.mpg.de/cone/journals/resource/954925536119