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  History Distribution Matching Method for Predicting Effectiveness of HIV Combination Therapies

Bogojeska, J. (2011). History Distribution Matching Method for Predicting Effectiveness of HIV Combination Therapies. In J. Shawe-Taylor, R. S. Zemel, P. Bartlett, F. Pereira, & K. Q. Weinberger (Eds.), Advances in Neural Information Processing Systems 24 (pp. 424-432). La Jolla, CA: NIPS Foundation.

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Genre: Konferenzbeitrag
Latex : History Distribution Matching Method for Predicting Effectiveness of {HIV} Combination Therapies

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Urheber

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 Urheber:
Bogojeska, Jasmina1, Autor           
Affiliations:
1Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society, ou_40046              

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Schlagwörter: -
 Zusammenfassung: This paper presents an approach that predicts the effectiveness of HIV combination therapies by simultaneously addressing several problems affecting the available HIV clinical data sets: the different treatment backgrounds of the samples, the uneven representation of the levels of therapy experience, the missing treatment history information, the uneven therapy representation and the unbalanced therapy outcome representation. The computational validation on clinical data shows that, compared to the most commonly used approach that does not account for the issues mentioned above, our model has significantly higher predictive power. This is especially true for samples stemming from patients with longer treatment history and samples associated with rare therapies. Furthermore, our approach is at least as powerful for the remaining samples.

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Sprache(n): eng - English
 Datum: 2011
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 618814
URI: http://books.nips.cc/papers/files/nips24/NIPS2011_0316.pdf
Anderer: Local-ID: C125673F004B2D7B-5AEE1AD9F23246E7C125797500392E26-Bogojeska2011
 Art des Abschluß: -

Veranstaltung

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Titel: Twenty-Fifth Annual Conference on Neural Information Processing Systems
Veranstaltungsort: Granada, Spain
Start-/Enddatum: 2011-12-12 - 2011-12-15

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Titel: Advances in Neural Information Processing Systems 24
  Kurztitel : NIPS 2011
Genre der Quelle: Konferenzband
 Urheber:
Shawe-Taylor, John1, Herausgeber
Zemel, Richard S.1, Herausgeber
Bartlett, Peter1, Herausgeber
Pereira, Fernando1, Herausgeber
Weinberger, Kilian Q.1, Herausgeber
Affiliations:
1 External Organizations, ou_persistent22            
Ort, Verlag, Ausgabe: La Jolla, CA : NIPS Foundation
Seiten: - Band / Heft: - Artikelnummer: - Start- / Endseite: 424 - 432 Identifikator: -