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  A Hox class 3 orthologue from the spider Cupiennius salei is expressed in a Hox-gene like fashion

Damen, W. G. M., & Tautz, D. (1998). A Hox class 3 orthologue from the spider Cupiennius salei is expressed in a Hox-gene like fashion. Development Genes and Evolution, 208(10), 586-590. doi:10.1007/s004270050218.

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Damen, W. G. M.1, Autor
Tautz, D.2, Autor           
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1external, ou_persistent22              
2External, ou_persistent22              

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 Zusammenfassung: The class 3 Hox gene orthologue in insects, zerknullt (zen), is not expressed along the anterior-posterior axis, but only in extra-embryonic tissues, suggesting that it has lost its function as a normal Hox gene. To analyse whether this loss of Hox gene function has already occurred in a basal arthropod lineage, we have isolated a Hox3 orthologue from the spider Cupiennius salei. In contrast to the insect ten sequences, which have a highly diverged homeobox, the spider Hox3 gene orthologue, Cs-Hox3, shows a high sequence similarity to the class 3 Hox genes of other phyla, including chordates. In situ hybridization in early embryos shows that it is expressed in a continuous region covering the pedipalp segment and the four leg-bearing segments. This expression pattern suggests a Hox-gene-like function for Cs-Hox3. On the other hand, the expression pattern does not strictly follow the colinearity rule, as it overlaps fully with the expression domain of the class 1 orthologue of the spider, Cs-lab. Still, our data suggest that the ancestor of the arthropods must have had a class 3 Hox gene with a function in anterior-posterior axis specification and that this function has been lost in the lineage leading to the insects.

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 Datum: 1998-121998-12
 Publikationsstatus: Erschienen
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 Identifikatoren: ISI: 000077352500006
DOI: 10.1007/s004270050218
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Titel: Development Genes and Evolution
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Berlin : Springer-Verlag
Seiten: - Band / Heft: 208 (10) Artikelnummer: - Start- / Endseite: 586 - 590 Identifikator: ISSN: 0949-944X
CoNE: https://pure.mpg.de/cone/journals/resource/954926988121