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  Genome-wide acceleration of protein evolution in flies (Diptera)

Savard, J., Tautz, D., & Lercher, M. J. (2006). Genome-wide acceleration of protein evolution in flies (Diptera). BMC Evolutionary Biology, 6. doi:10.1186/1471-2148-6-7.

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Datensatz-Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-0E2E-F Versions-Permalink: http://hdl.handle.net/11858/00-001M-0000-0010-0E2F-D
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 Urheber:
Savard, J.1, Autor
Tautz, D.2, Autor              
Lercher, M. J.1, Autor
Affiliations:
1external, escidoc:persistent22              
2External, escidoc:persistent22              

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 Zusammenfassung: Background: The rate of molecular evolution varies widely between proteins, both within and among lineages. To what extent is this variation influenced by genome-wide, lineage-specific effects? To answer this question, we assess the rate variation between insect lineages for a large number of orthologous genes. Results: When compared to the beetle Tribolium castaneum, we find that the stem lineage of flies and mosquitoes (Diptera) has experienced on average a 3-fold increase in the rate of evolution. Pairwise gene comparisons between Drosophila and Tribolium show a high correlation between evolutionary rates of orthologous proteins. Conclusion: Gene specific divergence rates remain roughly constant over long evolutionary times, modulated by genome-wide, lineage-specific effects. Among the insects analysed so far, it appears that the Tribolium genes show the lowest rates of divergence. This has the practical consequence that homology searches for human genes yield significantly better matches in Tribolium than in Drosophila. We therefore suggest that Tribolium is better suited for comparisons between phyla than the widely employed dipterans.

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 Datum: 20062006
 Publikationsstatus: Im Druck publiziert
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 Ort, Verlag, Ausgabe: -
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 Art der Begutachtung: -
 Identifikatoren: ISI: 000235335100001
DOI: 10.1186/1471-2148-6-7
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Titel: BMC Evolutionary Biology
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: BioMed Central
Seiten: - Band / Heft: 6 Artikelnummer: - Start- / Endseite: - Identifikator: ISSN: 1471-2148
CoNE: http://pubman.mpdl.mpg.de/cone/journals/resource/111000136905006