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  Wave-like spread of Ebola Zaire

Walsh, P. D., Biek, R., & Real, L. A. (2005). Wave-like spread of Ebola Zaire. PLoS Biology, 3(11): e371. doi:10.1371/journal.pbio.0030371.

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Walsh_Wave-like_PlosBiology_2005.pdf (Verlagsversion), 331KB
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Walsh_Wave-like_PlosBiology_2005.pdf
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2005
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Copyright: © 2005 Walsh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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 Urheber:
Walsh, Peter D.1, Autor           
Biek, Roman, Autor
Real, Leslie A., Autor
Affiliations:
1Department of Primatology, Max Planck Institute for Evolutionary Anthropology, Max Planck Society, ou_1497674              

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 Zusammenfassung: In the past decade the Zaire strain of Ebola virus (ZEBOV) has emerged repeatedly into human populations in central Africa and caused massive die-offs of gorillas and chimpanzees. We tested the view that emergence events are independent and caused by ZEBOV variants that have been long resident at each locality. Phylogenetic analyses place the earliest known outbreak at Yambuku, Democratic Republic of Congo, very near to the root of the ZEBOV tree, suggesting that viruses causing all other known outbreaks evolved from a Yambuku-like virus after 1976. The tendency for earlier outbreaks to be directly ancestral to later outbreaks suggests that outbreaks are epidemiologically linked and may have occurred at the front of an advancing wave. While the ladder-like phylogenetic structure could also bear the signature of positive selection, our statistical power is too weak to reach a conclusion in this regard. Distances among outbreaks indicate a spread rate of about 50 km per year that remains consistent across spatial scales. Viral evolution is clocklike, and sequences show a high level of small-scale spatial structure. Genetic similarity decays with distance at roughly the same rate at all spatial scales. Our analyses suggest that ZEBOV has recently spread across the region rather than being long persistent at each outbreak locality. Controlling the impact of Ebola on wild apes and human populations may be more feasible than previously recognized.

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Sprache(n): eng - English
 Datum: 2005
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 251099
DOI: 10.1371/journal.pbio.0030371
 Art des Abschluß: -

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Titel: PLoS Biology
  Andere : PLoS Biol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Public Library of Science
Seiten: - Band / Heft: 3 (11) Artikelnummer: e371 Start- / Endseite: - Identifikator: ISSN: 1544-9173
CoNE: https://pure.mpg.de/cone/journals/resource/111056649444170