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  A subset of dopamine neurons signals reward for odour memory in Drosophila

Liu, C., Placais, P.-Y., Yamagata, N., Pfeiffer, B. D., Aso, Y., Friedrich, A. B., et al. (2012). A subset of dopamine neurons signals reward for odour memory in Drosophila. NATURE, 488(7412), 512-516. doi:10.1038/nature11304.

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 Urheber:
Liu, Chang1, Autor           
Placais, Pierre-Yves2, Autor
Yamagata, Nobuhiro1, Autor           
Pfeiffer, Barret D.2, Autor
Aso, Yoshinori1, Autor           
Friedrich, Anja Beatrice1, Autor           
Siwanowicz, Igor1, Autor           
Rubin, Gerald M.2, Autor
Preat, Thomas2, Autor
Tanimoto, Hiromu1, Autor           
Affiliations:
1Max Planck Research Group: Behavioral Genetics / Tanimoto, MPI of Neurobiology, Max Planck Society, ou_1113555              
2external, ou_persistent22              

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Schlagwörter: TARGETED GENE-EXPRESSION; MUSHROOM BODY; BRAIN; FLY; HYDROXYLASE; OCTOPAMINE; SEROTONIN; BEHAVIOR; REVEALS; AROUSAL
 Zusammenfassung: Animals approach stimuli that predict a pleasant outcome(1). After the paired presentation of an odour and a reward, Drosophila melanogaster can develop a conditioned approach towards that odour(2,3). Despite recent advances in understanding the neural circuits for associative memory and appetitive motivation(4), the cellular mechanisms for reward processing in the fly brain are unknown. Here we show that a group of dopamine neurons in the protocerebral anterior medial (PAM) cluster signals sugar reward by transient activation and inactivation of target neurons in intact behaving flies. These dopamine neurons are selectively required for the reinforcing property of, but not a reflexive response to, the sugar stimulus. In vivo calcium imaging revealed that these neurons are activated by sugar ingestion and the activation is increased on starvation. The output sites of the PAM neurons are mainly localized to the medial lobes of the mushroom bodies (MBs), where appetitive olfactory associative memory is formed(5,6). We therefore propose that the PAM cluster neurons endow a positive predictive value to the odour in the MBs. Dopamine in insects is known to mediate aversive reinforcement signals(5,7-11). Our results highlight the cellular specificity underlying the various roles of dopamine and the importance of spatially segregated local circuits within the MBs.

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Sprache(n): eng - English
 Datum: 2012-08-23
 Publikationsstatus: Erschienen
 Seiten: 5
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 000307761600037
DOI: 10.1038/nature11304
 Art des Abschluß: -

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Titel: NATURE
Genre der Quelle: Zeitschrift
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Affiliations:
Ort, Verlag, Ausgabe: MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND : NATURE PUBLISHING GROUP
Seiten: - Band / Heft: 488 (7412) Artikelnummer: - Start- / Endseite: 512 - 516 Identifikator: ISSN: 0028-0836