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Schlagwörter:
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Zusammenfassung:
The FUT2 (Secretor) gene is responsible for the presence of ABO
histo-blood group antigens on the gastrointestinal mucosa and in
bodily secretions. Individuals lacking a functional copy of FUT2 are
known as “nonsecretors” and display an array of differences in
susceptibility to infection and disease, including Crohn disease. To
determine whether variation in resident microbial communities
with respect to FUT2 genotype is a potential factor contributing
to susceptibility, we performed 454-based community profiling of
the intestinal microbiota in a panel of healthy subjects and Crohn
disease patients and determined their genotype for the primary
nonsecretor allele in Caucasian populations, W143X (G428A). Consistent
with previous studies, we observe significant deviations in
the microbial communities of individuals with Crohn disease. Furthermore,
the FUT2 genotype explains substantial differences in
community composition, diversity, and structure, and we identified
several bacterial species displaying disease-by-genotype associations.
These findings indicate that alterations in resident microbial
communities may in part explain the variety of host susceptibilities
surrounding nonsecretor status and that FUT2 is an important genetic
factor influencing host–microbial diversity.
