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  The Effects of GluA1 Deletion on the Hippocampal Population Code for Position

Resnik, E., McFarland, J. M., Sprengel, R., Sakmann, B., & Mehta, M. R. (2012). The Effects of GluA1 Deletion on the Hippocampal Population Code for Position. JOURNAL OF NEUROSCIENCE, 32(26), 8952-8968. doi:10.1523/JNEUROSCI.6460-11.2012.

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Resnik, Evgeny1, Autor
McFarland, James M.1, Autor
Sprengel, Rolf1, Autor
Sakmann, Bert2, Autor           
Mehta, Mayank R.1, Autor
Affiliations:
1External Organizations, ou_persistent22              
2Emeritus Group: Cortical Column in silico / Sakmann, MPI of Neurobiology, Max Planck Society, ou_1113549              

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Schlagwörter: FREELY-MOVING RAT; A-DEFICIENT MICE; SPATIAL WORKING-MEMORY; LONG-TERM POTENTIATION; COMPLEX-SPIKE CELLS; PLACE CELLS; ENTORHINAL CORTEX; KNOCKOUT MICE; SYNAPTIC PLASTICITY; ENSEMBLE CODE
 Zusammenfassung: The GluA1 subunit of AMPA receptors (AMPARs) is critical for hippocampal synaptic transmission and plasticity. Here, we measured the activity of single units from the CA1 region of the hippocampus while GluA1 knock-out (GluA1(-/-)) and wild-type (WT) mice traversed a linear track. Although overall firing rates were similar, GluA1(-/-) neurons were more likely to spike in bursts, but at lower burst frequencies, compared with WT neurons. GluA1(-/-) neurons showed large reductions in all measures of spatial and directional selectivity compared with WT neurons. Consistent with these alterations of single-neuron properties, the accuracy of the population code for position was substantially reduced in GluA1(-/-), yet it is predicted to approach the accuracy of WT with increasing population size. The absolute representation of space, independent of movement direction, was greatly diminished in GluA1(-/-) mice and is predicted to remain reduced even for larger populations. Finally, we found that the rate maps of GluA1(-/-) neurons showed increased trial-by-trial variability but reduced experiential plasticity compared with the WT. These results reveal the critical contribution of GluA1-containing AMPARs to individual place cells and the hippocampal population code for space, which could explain the selective behavioral impairments observed in these mice.

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Sprache(n): eng - English
 Datum: 2012-06-27
 Publikationsstatus: Erschienen
 Seiten: 17
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: ISI: 000305890700019
DOI: 10.1523/JNEUROSCI.6460-11.2012
 Art des Abschluß: -

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Titel: JOURNAL OF NEUROSCIENCE
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA : SOC NEUROSCIENCE
Seiten: - Band / Heft: 32 (26) Artikelnummer: - Start- / Endseite: 8952 - 8968 Identifikator: ISSN: 0270-6474