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  Innate versus adaptive immunity in sticklebacks: evidence for trade-offs from a selection experiment

Wegner, K. M., Kalbe, M., & Reusch, T. B. H. (2007). Innate versus adaptive immunity in sticklebacks: evidence for trade-offs from a selection experiment. Evolutionary Ecology, 21(4), 473-483. doi:10.1007/s10682-006-9129-5.

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 Urheber:
Wegner, K. Mathias1, Autor           
Kalbe, Martin1, 2, Autor           
Reusch, Thorsten B. H.1, 3, Autor           
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              
2Research Group Parasitology, Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445643              
3Department Ecophysiology, Max Planck Institute for Limnology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_976547              

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Schlagwörter: Major histocompatibility complex (MHC); Ecological immunity; Innate resistance; Adaptive immunity; Gene expression; Three-spined stickleback (Gasterosteus aculeatus); Parasites; Artificial selection
 Zusammenfassung: In vertebrates, the immune system consists of two arms of different characteristics: the innate and the acquired immune response. Parasites that are only shortly exposed to the immune system are most efficiently attacked by fast, constitutive innate immune mechanisms. Here, we experimentally selected within four fish families for high innate resistance versus susceptibility of three-spined sticklebacks (Gasterosteus aculeatus) against infection with the eye-fluke (Diplostomum pseudospathacaeum), a parasite whose metacercariae are protected from the immune system within the eye lens. We predicted that in families with high susceptibility, the adaptive immune system would be upregulated when challenged with infection. In accordance, we found that MHC class IIB expression is increased by approximately 50% in those lines selected for higher parasite load (i.e. low innate response). This suggests extensive genetic correlations between innate and adaptive immune system and/or crosstalk between both lines of defense. An efficient, specific innate immune response might reduce overall activation of the immune system and potentially alleviate associated effects of immunopathology.

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Sprache(n): eng - English
 Datum: 2007-07
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Identifikatoren: eDoc: 307654
DOI: 10.1007/s10682-006-9129-5
Anderer: 2562/S 38712
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Titel: Evolutionary Ecology
  Alternativer Titel : Evol Ecol
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 21 (4) Artikelnummer: - Start- / Endseite: 473 - 483 Identifikator: ISSN: 0269-7653 (Print)
ISSN: 1573-8477 (Online)