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  Comparative lesion sequencing provides insights into tumor evolution

Jones, S., Chen, W.-d., Parmigiana, G., Diehl, F., Beerenwinkel, N., Antal, T., et al. (2008). Comparative lesion sequencing provides insights into tumor evolution. Proceedings of the National Academy of Sciences of the United States of America, 105(11), 4283-4288. doi:10.1073/pnas.0712345105.

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Jones, S., et al., 2008, S-38774.pdf (Publisher version), 839KB
 
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Jones, S., et al., 2008, S-38774.pdf
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 Creators:
Jones, Siân, Author
Chen, Wei-dong, Author
Parmigiana, Giovanni, Author
Diehl, Frank, Author
Beerenwinkel, Niko, Author
Antal, Tibor, Author
Traulsen, Arne1, 2, Author           
Nowak, Martin A., Author
Siegel, Christopher, Author
Velculescu, Victor E., Author
Kinzler, Kenneth W., Author
Vogelstein, Bert, Author
Willis, Joseph, Author
Markowitz, Sanford D., Author
Affiliations:
1Department Evolutionary Ecology, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445634              
2Research Group Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445641              

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Free keywords: cancer genetics; colorectal cancer; metastasis; stem cells
 Abstract: We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical observations, these analyses suggest the following general conclusions about colorectal tumorigenesis: (i) It takes approximate to 17 years for a large benign tumor to evolve into an advanced cancer but <2 years for cells within that cancer to acquire the ability to metastasize; (it) it requires few, if any, selective events to transform a highly invasive cancer cell into one with the capacity to metastasize; (iii) the process of cell culture ex vivo does not introduce new clonal mutations into colorectal tumor cell populations; and (iv) the rates at which point mutations develop in advanced cancers are similar to those of normal cells. These results have important implications for understanding human tumor pathogenesis, particularly those associated with metastasis.

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Language(s): eng - English
 Dates: 2008-03-18
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: eDoc: 361815
DOI: 10.1073/pnas.0712345105
Other: 2609/S 38774
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Alternative Title : PNAS
Source Genre: Journal
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Pages: - Volume / Issue: 105 (11) Sequence Number: - Start / End Page: 4283 - 4288 Identifier: ISSN: 0027-8424