hide
Language(s):
eng - English
Dates:
2009-05-25
Publication Status:
Accepted / In Press
Pages:
XVII, 77 Bl.
Publishing info:
Köln : Universität Köln
Table of Contents:
Table of Contents
Dedication .......................................................................................................... i
Epigraph ........................................................................................................... iii
List of Tables and Figures ................................................................................... vii
List of Abbreviations ........................................................................................... ix
Acknowledgments ............................................................................................... xi
Zusammenfassung ............................................................................................. xiii
Abstract ............................................................................................................xv
De claration...................................................................................................... xvii
1.0 Introduction .............................................................................................. 1
1.1 Mus musculus ssps.: A Model for Evolutionary Gene tics ............................ 1
1.1.1 The Origins of Mus musculus ssps. ...................................................... 1
1.2 A Portrait of Copy Number Variation .................................................. 3
1.2.1 The Genomic Landsc ape of Copy Number Variation ........................... 3
1.2.2 Cons equenc es of Copy Number Variation ......................................... 5
1.2.3 The Origin of Copy Number Variations ............................................ 7
1.3 Gene tic Divergence and Reproduc tive Isolation ................................... 11
1.3.1 Spe ciation Genetics of Mus musculus ssps. ......................................... 11
1.3.2 The Xlr Superfamily ..................................................................... 13
1.4 The Aim and Relevanc e of this study.................................................. 15
2.0 CNV De stabilization Mus musculus ssp. Hybrids ............................................. 17
2.1 The Slx Gene Family........................................................................ 17
2.1.1 Genomic Architec ture ................................................................... 17
2.1.2 Variation in Slx cDNA .................................................................. 18
2.2 CNV De stabilizations in Intersubspecific Hybrids ............................... 21
2.2.1 CNVs in Wild Populations ............................................................. 21
2.2.2 CNVs in Wild Hybrid Populations .................................................. 25
2.3 CNVs in Laboratory-Bred Hybrids .................................................... 31
2.3.1 CNVs in the F1 and F2 Generation ................................................. 31
2.3.2 De te c tion of CNV Des tabilization by aCGH ................................... 36
2.4 Discussion ..................................................................................... 40
3.0 DNA Repair Pathways in Hybrid Mice .......................................................... 43
3.1 Genome Maintenanc e and Instability ................................................. 43
3.2 Organogenesis and Genome Maintenanc e ........................................... 44
3.3 Experimental Outline ...................................................................... 45
3.4 A Description of Embryonic DNA Repair Pathways ............................. 49
3.5 Discussion ..................................................................................... 56
4.0 Concluding Remarks ................................................................................. 61
4.1 A General Summary ........................................................................ 61
4.2 Novel Alleles and Hybrid Spe ciation .................................................. 61
4.3 Outloo k ........................................................................................ 62
5.0 Materials & Methods ................................................................................. 63
6.0 Re ferenc es ............................................................................................... 67
7.0 Lebenslauf ............................................................................................... 79
Rev. Type:
-
Identifiers:
eDoc: 457049
Other: Diss/12201
Degree:
PhD
