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  Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer

Chan, Y. F., Marks, M. E., Jones, F. C., Villarreal Jr., G., Shapiro, M. D., Brady, S. D., et al. (2010). Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a Pitx1 enhancer. Science, 327(5963), 302-305. doi:10.1126/science.1182213.

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Chan, Yingguang Frank1, Author           
Marks, Melissa E., Author
Jones, Felicity C., Author
Villarreal Jr., Guadalupe, Author
Shapiro, Michael D., Author
Brady, Shannon D., Author
Southwick, Audrey M., Author
Absher, Devin M., Author
Grimwood, Jane, Author
Schmutz, Jeremy, Author
Myers, Richard M., Author
Petrov, Dmitri, Author
Jónsson, Bjarni, Author
Schluter, Dolph, Author
Bell, Michael A., Author
Kingsley, David M., Author
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1Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_1445635              

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 Abstract: The molecular mechanisms underlying major phenotypic changes that have evolved repeatedly in nature are generally unknown. Pelvic loss in different natural populations of threespine stickleback fish has occurred through regulatory mutations deleting a tissue-specific enhancer of the Pituitary homeobox transcription factor 1 (Pitx1) gene. The high prevalence of deletion mutations at Pitx1 may be influenced by inherent structural features of the locus. Although Pitx1 null mutations are lethal in laboratory animals, Pitx1 regulatory mutations show molecular signatures of positive selection in pelvic-reduced populations. These studies illustrate how major expression and morphological changes can arise from single mutational leaps in natural populations, producing new adaptive alleles via recurrent regulatory alterations in a key developmental control gene.

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Language(s): eng - English
 Dates: 2010-01-15
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
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 Identifiers: eDoc: 572152
DOI: 10.1126/science.1182213
Other: 2865/S 39208
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Title: Science
Source Genre: Journal
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Pages: - Volume / Issue: 327 (5963) Sequence Number: - Start / End Page: 302 - 305 Identifier: ISSN: 0036-8075 (print)
ISSN: 1095-9203 (online)