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  How short-ranged electrostatics controls the chromatin structure on much larger scales

Schiessel, H. (2002). How short-ranged electrostatics controls the chromatin structure on much larger scales. Europhysics Letters, 58(1), 140-146.

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 Creators:
Schiessel, H.1, Author           
Affiliations:
1MPI for Polymer Research, Max Planck Society, ou_1309545              

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 Abstract: We propose that the degree of swelling of the 30 nm chromatin fiber (a "measure" of its transcriptional activity) is mainly determined by the short-ranged electrostatical interaction between different sections of the "folded" DNA chain. These sections constitute only a small fraction of the chain and they are located close to the entry-exit points of the DNA chain at the nucleosome core particles. We present a model that allows to estimate the degree of swelling of chromatin fibers as a function of salt concentration, charge density of the strands, etc. Different mechanisms by which the state of chromatin can be controlled in vitro and in vivo are discussed.

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Language(s): eng - English
 Dates: 2002-04
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: No review
 Identifiers: eDoc: 28512
ISI: 000174756300022
Other: P-02-161
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Title: Europhysics Letters
  Alternative Title : Europhys. Lett.
Source Genre: Journal
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Publ. Info: -
Pages: - Volume / Issue: 58 (1) Sequence Number: - Start / End Page: 140 - 146 Identifier: ISSN: 0295-5075