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  Nucleosome repositioning via loop formation

Kulic, I. M., & Schiessel, H. (2003). Nucleosome repositioning via loop formation. Biophysical Journal, 84(5), 3197-3211.

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 Urheber:
Kulic, I. M.1, Autor           
Schiessel, Helmut1, Autor           
Affiliations:
1MPI for Polymer Research, Max Planck Society, ou_1309545              

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 Zusammenfassung: Active (catalyzed) and passive (intrinsic) nucleosome repositioning is known to be a crucial event during the transcriptional activation of certain eukaryotic genes. Here we consider theoretically the intrinsic mechanism and study in detail the energetics and dynamics of DNA-loop-mediated nucleosome repositioning, as previously proposed by earlier works. The surprising outcome of the present study is the inherent nonlocality of nucleosome motion within this model-being a direct physical consequence of the loop mechanism. On long enough DNA templates the longer jumps dominate over the previously predicted local motion, a fact that contrasts simple diffusive mechanisms considered before. The possible experimental outcome resulting from the considered mechanism is predicted, discussed, and compared to existing experimental findings.

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Sprache(n): eng - English
 Datum: 2003-05
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: eDoc: 51093
ISI: 000183123200037
Anderer: P-03-261
 Art des Abschluß: -

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Titel: Biophysical Journal
  Alternativer Titel : Biophys. J.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 84 (5) Artikelnummer: - Start- / Endseite: 3197 - 3211 Identifikator: ISSN: 0006-3495