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  Identification of common variants associated with human hippocampal and intracranial volumes

Stein, J. L., Medland, S. E., Vasquez, A. A., Hibar, D. P., Senstad, R. E., Winkler, A. M., et al. (2012). Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics, 44, 552-561. doi:10.1038/ng.2250.

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Stein, Jason L, Author
Medland, Sarah E, Author
Vasquez, Alejandro Arias, Author
Hibar, Derrek P, Author
Senstad, Rudy E, Author
Winkler, Anderson M, Author
Toro, Roberto, Author
Appel, Katja, Author
Bartecek, Richard, Author
Bergmann, Ørjan, Author
Bernard, Manon, Author
Brown, Andrew A, Author
Cannon, Dara M, Author
Chakravarty, M Mallar, Author
Christoforou, Andrea, Author
Domin, Martin, Author
Grimm, Oliver, Author
Hollinshead, Marisa, Author
Holmes, Avram J, Author
Homuth, Georg, Author
Hottenga, Jouke-Jan, AuthorLangan, Camilla, AuthorLopez, Lorna M, AuthorHansell, Narelle K, AuthorHwang, Kristy S, AuthorKim, Sungeun, AuthorLaje, Gonzalo, AuthorLee, Phil H, AuthorLiu, Xinmin, AuthorLoth, Eva, AuthorLourdusamy, Anbarasu, AuthorMattingsdal, Morten, AuthorMohnke, Sebastian, AuthorManiega, Susana Muñoz, AuthorNho, Kwangsik, AuthorNugent, Allison C, AuthorO'Brien, Carol, AuthorPapmeyer, Martina, AuthorPütz, Benno, AuthorRamasamy, Adaikalavan, AuthorRasmussen, Jerod, AuthorRijpkema, Mark, AuthorRisacher, Shannon L, AuthorRoddey, J Cooper, AuthorRose, Emma J, AuthorRyten, Mina, AuthorShen, Li, AuthorSprooten, Emma, AuthorStrengman, Eric, AuthorTeumer, Alexander, AuthorTrabzuni, Daniah, AuthorTurner, Jessica, Authorvan Eijk, Kristel, Authorvan Erp, Theo G M, Authorvan Tol, Marie-Jose, AuthorWittfeld, Katharina, AuthorWolf, Christiane, AuthorWoudstra, Saskia, AuthorAleman, Andre, AuthorAlhusaini, Saud, AuthorAlmasy, Laura, AuthorBinder, Elisabeth B, AuthorBrohawn, David G, AuthorCantor, Rita M, AuthorCarless, Melanie A, AuthorCorvin, Aiden, AuthorCzisch, Michael, AuthorCurran, Joanne E, AuthorDavies, Gail, Authorde Almeida, Marcio A A, AuthorDelanty, Norman, AuthorDepondt, Chantal, AuthorDuggirala, Ravi, AuthorDyer, Thomas D, AuthorErk, Susanne, AuthorFagerness, Jesen, AuthorFox, Peter T, AuthorFreimer, Nelson B, AuthorGill, Michael, AuthorGöring, Harald H H, AuthorHagler, Donald J, AuthorHoehn, David, AuthorHolsboer, Florian, AuthorHoogman, Martine1, 2, Author           Hosten, Norbert, AuthorJahanshad, Neda, AuthorJohnson, Matthew P, AuthorKasperaviciute, Dalia, AuthorKent, Jack W Jr., AuthorKochunov, Peter, AuthorLancaster, Jack L, AuthorLawrie, Stephen M, AuthorLiewald, David C, AuthorMandl, René, AuthorMatarin, Mar, AuthorMattheisen, Manuel, AuthorMeisenzahl, Eva, AuthorMelle, Ingrid, AuthorMoses, Eric K, AuthorMühleisen, Thomas W, AuthorNauck, Matthias, AuthorNöthen, Markus M, AuthorOlvera, Rene L, AuthorPandolfo, Massimo, AuthorPike, G Bruce, AuthorPuls, Ralf, AuthorReinvang, Ivar, AuthorRentería, Miguel E, AuthorRietschel, Marcella, AuthorRoffman, Joshua L, AuthorRoyle, Natalie A, AuthorRujescu, Dan, AuthorSavitz, Jonathan, AuthorSchnack, Hugo G, AuthorSchnell, Knut, AuthorSeiferth, Nina, AuthorSmith, Colin, AuthorHernández, Maria C Valdés, AuthorSteen, Vidar M., Authorden Heuvel, Martijn Van, Authorvan der Wee, Nic J, AuthorHaren, Neeltje E M Van, AuthorVeltman, Joris A, AuthorVölzke, Henry, AuthorWalker, Robert, AuthorWestlye, Lars T, AuthorWhelan, Christopher D, AuthorAgartz, Ingrid, AuthorBoomsma, Dorret I, AuthorCavalleri, Gianpiero L, AuthorDale, Anders M, AuthorDjurovic, Srdjan, AuthorDrevets, Wayne C, AuthorHagoort, Peter1, 3, Author           Hall, Jeremy, AuthorHeinz, Andreas, AuthorClifford, R Jack, AuthorForoud, Tatiana M, AuthorLe Hellard, Stephanie, AuthorMacciardi, Fabio, AuthorMontgomery, Grant W, AuthorPoline, Jean Baptiste, AuthorPorteous, David J, AuthorSisodiya, Sanjay M, AuthorStarr, John M, AuthorSussmann, Jessika, AuthorToga, Arthur W, AuthorVeltman, Dick J, AuthorWalter, Henrik, AuthorWeiner, Michael W, AuthorEPIGEN Consortium, Author              IMAGENConsortium, Author              Saguenay Youth Study Group, Author              Bis, Joshua C, AuthorIkram, M Arfan, AuthorSmith, Albert V, AuthorGudnason, Vilmundur, AuthorTzourio, Christophe, AuthorVernooij, Meike W, AuthorLauner, Lenore J, AuthorDeCarli, Charles, AuthorSeshadri, Sudha, AuthorHeart, Cohorts for, AuthorConsortium, Aging Research in Genomic Epidemiology (CHARGE), AuthorAndreassen, Ole A, AuthorApostolova, Liana G, AuthorBastin, Mark E, AuthorBlangero, John, AuthorBrunner, Han G, AuthorBuckner, Randy L, AuthorCichon, Sven, AuthorCoppola, Giovanni, Authorde Zubicaray, Greig I, AuthorDeary, Ian J, AuthorDonohoe, Gary, Authorde Geus, Eco J C, AuthorEspeseth, Thomas, AuthorFernández, Guillén, AuthorGlahn, David C, AuthorGrabe, Hans J, AuthorHardy, John, AuthorHulshoff Pol, Hilleke E , AuthorJenkinson, Mark, AuthorKahn, René S, AuthorMcDonald, Colm, AuthorMcIntosh, Andrew M, AuthorMcMahon, Francis J, AuthorMcMahon, Katie L, AuthorMeyer-Lindenberg, Andreas, AuthorMorris, Derek W, AuthorMüller-Myhsok, Bertram, AuthorNichols, Thomas E, AuthorOphoff, Roel A, AuthorPaus, Tomas, AuthorPausova, Zdenka, AuthorPenninx, Brenda W, AuthorSämann, Philipp G, AuthorSaykin, Andrew J, AuthorSchumann, Gunter, AuthorSmoller, Jordan W, AuthorWardlaw, Joanna M, AuthorWeale, Michael E, AuthorMartin, Nicholas G, AuthorFranke, Barbara, AuthorWright, Margaret J, AuthorThompson, Paul M, Authorthe Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium, Author               more..
Affiliations:
1Donders Institute for Brain, Cognition and Behaviour, External Organizations, ou_55236              
2Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society, ou_792549              
3Neurobiology of Language Department, MPI for Psycholinguistics, Max Planck Society, ou_792551              

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 Abstract: Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10(-16)) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10(-12)). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10(-7)).

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Language(s): eng - English
 Dates: 201220122012
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/ng.2250
PMID: 22504417
 Degree: -

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Title: Nature Genetics
  Other : Nature Genet.
Source Genre: Journal
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Publ. Info: New York, NY : Nature America, Inc.
Pages: - Volume / Issue: 44 Sequence Number: - Start / End Page: 552 - 561 Identifier: ISSN: 1061-4036
CoNE: https://pure.mpg.de/cone/journals/resource/954925598609