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  Stable coreceptor usage of HIV in patients with ongoing treatment failure on HAART

Lehmann, C., Däumer, M., Bousaad, I., Sing, T., Beerenwinkel, N., Lengauer, T., et al. (2006). Stable coreceptor usage of HIV in patients with ongoing treatment failure on HAART. Journal of Clinical Virology, 37, 300-304.

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Lehmann, Clara, Autor
Däumer, Martin, Autor
Bousaad, Ibrahim, Autor
Sing, Tobias1, Autor           
Beerenwinkel, Niko1, Autor           
Lengauer, Thomas1, Autor           
Schmeisser, Norbert, Autor
Wyen, Christoph, Autor
Fätkenheuer, Gerd, Autor
Kaiser, Rolf, Autor
Affiliations:
1Computational Biology and Applied Algorithmics, MPI for Informatics, Max Planck Society, ou_40046              

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 Zusammenfassung: Background Disease progression in HIV infection has been associated with switch of viral coreceptor usage from CCR5 to CXCR4. Objectives To investigate the relationship between HIV-coreceptor tropism and clinical and virological outcome in 40 heavily pretreated patients over time. Methods Coreceptor phenotype was predicted after sequencing the V3 loop of the HIV glycoprotein 120. Results Coreceptor use was stable during observation time in 87% of patients, and CCR5 tropism was predominant. Viral mutations in the pol gene and clinical parameters were not predictive for coreceptor switching. Conclusions Even in patients with repeated HAART failure, CCR5 antagonists might be a valuable treatment option.

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Sprache(n): eng - English
 Datum: 2007-03-052006
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 314398
Anderer: Local-ID: C125673F004B2D7B-82595EA0165C7592C125725F00318E9C-Lengauer2006g
 Art des Abschluß: -

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Titel: Journal of Clinical Virology
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 37 Artikelnummer: - Start- / Endseite: 300 - 304 Identifikator: -