Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Neuregulin-1 isoforms are differentially expressed in the intact and regenerating adult rat nervous system

Kerber, G., Streif, R., Schwaiger, F. W., Kreutzberg, G. W., & Hager, G. (2003). Neuregulin-1 isoforms are differentially expressed in the intact and regenerating adult rat nervous system. Journal of Molecular Neuroscience, 21(2), 149-165.

Item is

Externe Referenzen

einblenden:

Urheber

einblenden:
ausblenden:
 Urheber:
Kerber, G.1, Autor
Streif, R.1, Autor
Schwaiger, F. W.2, Autor           
Kreutzberg, G. W.2, Autor           
Hager, G.2, Autor           
Affiliations:
1Max Planck Inst Neurobiol, D-82151 Martinsried, Germany., ou_persistent22              
2Emeritus Group: Neuromorphology / Kreutzberg, MPI of Neurobiology, Max Planck Society, ou_1113551              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: Our knowledge on Neuregulin-1 (Nrg-1) during development of the nervous system is increasing rapidly, but little is known about Nrg-1-ErbB signaling in the adult brain. Nrg-1 is involved in determination, proliferation, differentiation, and migration of neurons and glial cells in the developing brain. In the peripheral nervous system, Nrg-1 signaling is required for Schwann cell differentiation and myelination, and establishment of neuromuscular junctions (NMjs). Multiple alternative splicing of Nrg-1 was shown, but correlation of its structural and functional diversity was rarely addressed. Therefore, we investigated the expression of Nrg-1 isoforms in the rat brain and brain-derived cell types, and their involvement in regeneration of the adult brain, using immunohistochemistry, in situ hybridization, and semiquantitative RT-PCR. We found expression of at least 12 distinct Nrg-1 isoforms in the brain and altered expression of several isoforms in the facial motor nucleus after peripheral transection of the seventh cranial nerve. An upregulation of Nrg-1 type-I mRNA, probably type-I-alpha, was observed in reactive astrocytes of the facial nucleus 1 d postaxotomy. Nrg-1 type-III and the splice variants beta1 and beta5 are dramatically downregulated in axotomized motoneurons, which lack contact to their target tissue. Baseline expression levels were reestablished when the first axons reached the facial muscles and reformed NMJs. Nrg-1-beta1 and -beta5 might act in maintenance of NMJs. The splice variants beta2 and beta4 display an initial downregulation of mRNA levels, followed by an increase during the period of axon remyelination. Thus, Nrg-1-beta2 and -beta4 might be involved in myelination.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2003
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: eDoc: 127691
ISI: 000186282300006
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Journal of Molecular Neuroscience
  Alternativer Titel : J. Mol. Neurosci.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 21 (2) Artikelnummer: - Start- / Endseite: 149 - 165 Identifikator: ISSN: 0895-8696