Study of 300,486 individuals identifies 148 independent genetic loci 
influencing general cognitive function

Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle; Hill, W. David; Hagenaars, Saskia P.; Ritchie, Stuart J.; Marioni, Riccardo E.; Fawns-Ritchie, Chloe; Liewald, David C. M.; Okely, Judith A.; Ahola-Olli, Ari V.; Barnes, Catriona L. K.; Bertram, Lars; Bis, Joshua C.; Burdick, Katherine E.; Christoforou, Andrea; DeRosse, Pamela; Djurovic, Srdjan; Espeseth, Thomas; Giakoumaki, Stella; Giddaluru, Sudheer; Gustavson, Daniel E.; Hayward, Caroline; Hofer, Edith; Ikram, M. Arfan; Karlsson, Robert; Knowles, Emma; Lahti, Jari; Leber, Markus; Li, Shuo; Mather, Karen A.; Melle, Ingrid; Morris, Derek; Oldmeadow, Christopher; Palviainen, Teemu; Payton, Antony; Pazoki, Raha; Petrovic, Katja; Reynolds, Chandra A.; Sargurupremraj, Muralidharan; Scholz, Markus; Smith, Jennifer A.; Smith, Albert V.; Terzikhan, Natalie; Thalamuthu, Anbupalam; Trompet, Stella; van der Lee, Sven J.; Ware, Erin B.; Windham, B. Gwen; Wright, Margaret J.; Yang, Jingyun; Yu, Jin; Ames, David; Amin, Najaf; Amouyel, Philippe; Andreassen, Ole A.; Armstrong, Nicola J.; Assareh, Amelia A.; Attia, John R.; Attix, Deborah; Avramopoulos, Dimitrios; Bennett, David A.; Böhmer, Anne C.; Boyle, Patricia A.; Brodaty, Henry; Campbell, Harry; Cannon, Tyrone D.; Cirulli, Elizabeth T.; Congdon, Eliza; Conley, Emily Drabant; Corley, Janie; Cox, Simon R.; Dale, Anders M.; Dehghan, Abbas; Dick, Danielle; Dickinson, Dwight; Eriksson, Johan G.; Evangelou, Evangelos; Faul, Jessica D.; Ford, Ian; Freimer, Nelson A.; Gao, He; Giegling, Ina; Gillespie, Nathan A.; Gordon, Scott D.; Gottesman, Rebecca F.; Griswold, Michael E.; Gudnason, Vilmundur; Harris, Tamara B.; Hartmann, Annette M.; Hatzimanolis, Alex; Heiss, Gerardo; Holliday, Elizabeth G.; Joshi, Peter K.; Kähönen, Mika; Kardia, Sharon L. R.; Karlsson, Ida; Kleineidam, Luca; Knopman, David S.; Kochan, Nicole A.; Konte, Bettina; Kwok, John B.; Le Hellard, Stephanie; Lee, Teresa; Lehtimäki, Terho; Li, Shu-Chen; Lill, Christina M.; Liu, Tian; Koini, Marisa; London, Edythe; Jr, Will T. Longstreth; Lopez, Oscar L.; Loukola, Anu; Luck, Tobias; Lundervold, Astri J.; Lundquist, Anders; Lyytikäinen, Leo-Pekka; Martin, Nicholas G.; Montgomery, Grant W.; Murray, Alison D.; Need, Anna C.; Noordam, Raymond; Nyberg, Lars; Ollier, William; Papenberg, Goran; Pattie, Alison; Polasek, Ozren; Poldrack, Russell A.; Psaty, Bruce M.; Reppermund, Simone; Riedel-Heller, Steffi G.; Rose, Richard J.; Rotter, Jerome I.; Roussos, Panos; Rovio, Suvi P.; Saba, Yasaman; Sabb, Fred W.; Sachdev, Perminder S.; Satizabal, Claudia L.; Schmid, Matthias; Scott, Rodney J.; Scult, Matthew A.; Simino, Jeannette; Slagboom, P. Eline; Smyrnis, Nikolaos; Soumaré, Aïcha; Stefanis, Nikos C.; Stott, David J.; Straub, Richard E.; Sundet, Kjetil; Taylor, Adele M.; Taylor, Kent D.; Tzoulaki, Ioanna; Tzourio, Christophe; Uitterlinden, André; Vitart, Veronique; Voineskos, Aristotle N.; Kaprio, Jaakko; Wagner, Michael; Wagner, Holger; Weinhold, Leonie; Wen, K. Hoyan; Widen, Elisabeth; Yang, Qiong; Zhao, Wei; Adams, Hieab H. H.; Arking, Dan E.; Bilder, Robert M.; Bitsios, Panos; Boerwinkle, Eric; Chiba-Falek, Ornit; Corvin, Aiden; Jager, Philip L. De; Debette, Stéphanie; Donohoe, Gary; Elliott, Paul; Fitzpatrick, Annette L.; Gill, Michael; Glahn, David C.; Hägg, Sara; Hansell, Narelle K.; Hariri, Ahmad R.; Ikram, M. Kamran; Jukema, J. Wouter; Vuoksimaa, Eero; Keller, Matthew C.; Kremen, William S.; Launer, Lenore; Lindenberger, Ulman; Palotie, Aarno; Pedersen, Nancy L.; Pendleton, Neil; Porteous, David J.; Räikkönen, Katri; Raitakari, Olli T.; Ramirez, Alfredo; Reinvang, Ivar; Rudan, Igor; Rujescu, Dan; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter W.; Schofield, Peter R.; Starr, John M.; Steen, Vidar M.; Trollor, Julian N.; Turner, Steven T.; Duijn, Cornelia M. Van; Villringer, Arno; Weinberger, Daniel R.; Weir, David R.; Wilson, James F.; Malhotra, Anil; McIntosh, Andrew M.; Gale, Catharine R.; Seshadri, Sudha; Jr, Thomas H. Mosley; Bressler, Jan; Deary, Todd Lencz & Ian J.

doi:10.1038/s41467-018-04362-x

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Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., et al. (2018). Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications, 9: 2098. doi:10.1038/s41467-018-04362-x.

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Davies, Gail, Autor
Lam, Max, Autor
Harris, Sarah E., Autor
Trampush, Joey W., Autor
Luciano, Michelle, Autor
Hill, W. David, Autor
Hagenaars, Saskia P., Autor
Ritchie, Stuart J., Autor
Marioni, Riccardo E., Autor
Fawns-Ritchie, Chloe, Autor
Liewald, David C. M., Autor
Okely, Judith A., Autor
Ahola-Olli, Ari V., Autor
Barnes, Catriona L. K., Autor
Bertram, Lars, Autor
Bis, Joshua C., Autor
Burdick, Katherine E., Autor
Christoforou, Andrea, Autor
DeRosse, Pamela, Autor
Djurovic, Srdjan, Autor
Espeseth, Thomas, AutorGiakoumaki, Stella, AutorGiddaluru, Sudheer, AutorGustavson, Daniel E., AutorHayward, Caroline, AutorHofer, Edith, AutorIkram, M. Arfan, AutorKarlsson, Robert, AutorKnowles, Emma, AutorLahti, Jari, AutorLeber, Markus, AutorLi, Shuo, AutorMather, Karen A., AutorMelle, Ingrid, AutorMorris, Derek, AutorOldmeadow, Christopher, AutorPalviainen, Teemu, AutorPayton, Antony, AutorPazoki, Raha, AutorPetrovic, Katja, AutorReynolds, Chandra A., AutorSargurupremraj, Muralidharan, AutorScholz, Markus, AutorSmith, Jennifer A., AutorSmith, Albert V., AutorTerzikhan, Natalie, AutorThalamuthu, Anbupalam, AutorTrompet, Stella, Autorvan der Lee, Sven J., AutorWare, Erin B., AutorWindham, B. Gwen, AutorWright, Margaret J., AutorYang, Jingyun, AutorYu, Jin, AutorAmes, David, AutorAmin, Najaf, AutorAmouyel, Philippe, AutorAndreassen, Ole A., AutorArmstrong, Nicola J., AutorAssareh, Amelia A., AutorAttia, John R., AutorAttix, Deborah, AutorAvramopoulos, Dimitrios, AutorBennett, David A., AutorBöhmer, Anne C., AutorBoyle, Patricia A., AutorBrodaty, Henry, AutorCampbell, Harry, AutorCannon, Tyrone D., AutorCirulli, Elizabeth T., AutorCongdon, Eliza, AutorConley, Emily Drabant, AutorCorley, Janie, AutorCox, Simon R., AutorDale, Anders M., AutorDehghan, Abbas, AutorDick, Danielle, AutorDickinson, Dwight, AutorEriksson, Johan G., AutorEvangelou, Evangelos, AutorFaul, Jessica D., AutorFord, Ian, AutorFreimer, Nelson A., AutorGao, He, AutorGiegling, Ina, AutorGillespie, Nathan A., AutorGordon, Scott D., AutorGottesman, Rebecca F., AutorGriswold, Michael E., AutorGudnason, Vilmundur, AutorHarris, Tamara B., AutorHartmann, Annette M., AutorHatzimanolis, Alex, AutorHeiss, Gerardo, AutorHolliday, Elizabeth G., AutorJoshi, Peter K., AutorKähönen, Mika, AutorKardia, Sharon L. R., AutorKarlsson, Ida, AutorKleineidam, Luca, AutorKnopman, David S., AutorKochan, Nicole A., AutorKonte, Bettina, AutorKwok, John B., AutorLe Hellard, Stephanie, AutorLee, Teresa, AutorLehtimäki, Terho, AutorLi, Shu-Chen, AutorLill, Christina M., AutorLiu, Tian, AutorKoini, Marisa, AutorLondon, Edythe, AutorJr, Will T. Longstreth, AutorLopez, Oscar L., AutorLoukola, Anu, AutorLuck, Tobias, AutorLundervold, Astri J., AutorLundquist, Anders, AutorLyytikäinen, Leo-Pekka, AutorMartin, Nicholas G., AutorMontgomery, Grant W., AutorMurray, Alison D., AutorNeed, Anna C., AutorNoordam, Raymond, AutorNyberg, Lars, AutorOllier, William, AutorPapenberg, Goran, AutorPattie, Alison, AutorPolasek, Ozren, AutorPoldrack, Russell A., AutorPsaty, Bruce M., AutorReppermund, Simone, AutorRiedel-Heller, Steffi G., AutorRose, Richard J., AutorRotter, Jerome I., AutorRoussos, Panos, AutorRovio, Suvi P., AutorSaba, Yasaman, AutorSabb, Fred W., AutorSachdev, Perminder S., AutorSatizabal, Claudia L., AutorSchmid, Matthias, AutorScott, Rodney J., AutorScult, Matthew A., AutorSimino, Jeannette, AutorSlagboom, P. Eline, AutorSmyrnis, Nikolaos, AutorSoumaré, Aïcha, AutorStefanis, Nikos C., AutorStott, David J., AutorStraub, Richard E., AutorSundet, Kjetil, AutorTaylor, Adele M., AutorTaylor, Kent D., AutorTzoulaki, Ioanna, AutorTzourio, Christophe, AutorUitterlinden, André, AutorVitart, Veronique, AutorVoineskos, Aristotle N., AutorKaprio, Jaakko, AutorWagner, Michael, AutorWagner, Holger, AutorWeinhold, Leonie, AutorWen, K. Hoyan, AutorWiden, Elisabeth, AutorYang, Qiong, AutorZhao, Wei, AutorAdams, Hieab H. H., AutorArking, Dan E., AutorBilder, Robert M., AutorBitsios, Panos, AutorBoerwinkle, Eric, AutorChiba-Falek, Ornit, AutorCorvin, Aiden, AutorJager, Philip L. De, AutorDebette, Stéphanie, AutorDonohoe, Gary, AutorElliott, Paul, AutorFitzpatrick, Annette L., AutorGill, Michael, AutorGlahn, David C., AutorHägg, Sara, AutorHansell, Narelle K., AutorHariri, Ahmad R., AutorIkram, M. Kamran, AutorJukema, J. Wouter, AutorVuoksimaa, Eero, AutorKeller, Matthew C., AutorKremen, William S., AutorLauner, Lenore, AutorLindenberger, Ulman, AutorPalotie, Aarno, AutorPedersen, Nancy L., AutorPendleton, Neil, AutorPorteous, David J., AutorRäikkönen, Katri, AutorRaitakari, Olli T., AutorRamirez, Alfredo, AutorReinvang, Ivar, AutorRudan, Igor, AutorRujescu, Dan, AutorSchmidt, Reinhold, AutorSchmidt, Helena, AutorSchofield, Peter W., AutorSchofield, Peter R., AutorStarr, John M., AutorSteen, Vidar M., AutorTrollor, Julian N., AutorTurner, Steven T., AutorDuijn, Cornelia M. Van, AutorVillringer, Arno¹, Autor Weinberger, Daniel R., AutorWeir, David R., AutorWilson, James F., AutorMalhotra, Anil, AutorMcIntosh, Andrew M., AutorGale, Catharine R., AutorSeshadri, Sudha, AutorJr, Thomas H. Mosley, AutorBressler, Jan, AutorDeary, Todd Lencz & Ian J., Autor mehr..

Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549

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Zusammenfassung: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16–102) and find 148 genome-wide significant independent loci (P < 5 × 10−8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.

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Sprache(n): eng - English

Datum: Eingereicht: 2017-08-31Angenommen: 2018-04-23Online veröffentlicht: 2018-05-29

Publikationsstatus: Online veröffentlicht

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Ort, Verlag, Ausgabe: -

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Art der Begutachtung: Expertenbegutachtung

Identifikatoren: DOI: 10.1038/s41467-018-04362-x
PMID: 29844566
PMC: PMC5974083

Art des Abschluß: -

Projektname : -

Grant ID : MR/K026992/1

Förderprogramm : -

Förderorganisation : Medical Research Council (MRC)

Projektname : -

Grant ID : R01 AG033193 ; U01 AG049505 ; U01 AG052409

Förderprogramm : -

Förderorganisation : National Institute on Aging

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Grant ID : -

Förderprogramm : -

Förderorganisation : Biotechnology and Biological Sciences Research Council (BBSRC)

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Titel: Nature Communications

Kurztitel : Nat. Commun.

Genre der Quelle: Zeitschrift

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Ort, Verlag, Ausgabe: London : Nature Publishing Group

Seiten: - Band / Heft: 9 Artikelnummer: 2098 Start- / Endseite: - Identifikator: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723

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