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  A whole-brain computational modeling approach to explain the alterations in resting-state functional connectivity during progression of Alzheimer's disease

Demirtaş, M., Falcon, C., Tucholka, A., Gispert, J. D., Molinuevo, J. L., & Deco, G. (2017). A whole-brain computational modeling approach to explain the alterations in resting-state functional connectivity during progression of Alzheimer's disease. NeuroImage: Clinical, 16, 343-354. doi:10.1016/j.nicl.2017.08.006.

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アイテムのパーマリンク: https://hdl.handle.net/11858/00-001M-0000-002E-2923-B 版のパーマリンク: https://hdl.handle.net/21.11116/0000-0005-51D2-2
資料種別: 学術論文

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Demirtas_Falcon_2017.pdf (出版社版), 2MB
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Demirtas_Falcon_2017.pdf
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 作成者:
Demirtaş, Murat1, 2, 著者
Falcon, Carles3, 4, 著者
Tucholka, Alan3, 著者
Gispert, Juan Domingo3, 4, 著者
Molinuevo, José Luis3, 著者
Deco, Gustavo1, 5, 6, 7, 著者           
所属:
1Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
2Department of Psychiatry, Yale University, New Haven, CT, USA, ou_persistent22              
3Pasqual Maragall Foundation, Barcelonabeta Brain Research Center, Barcelona, Spain, ou_persistent22              
4CIBER-BBN: Consorcio Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Zaragoza, Spain, ou_persistent22              
5Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
6Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634551              
7School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

内容説明

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キーワード: Resting state fMRI; Dynamic functional connectivity; Computational modeling; Alzheimer's disease; Biomarkers
 要旨: Alzheimer's disease (AD) is the most common dementia with dramatic consequences. The research in structural and functional neuroimaging showed altered brain connectivity in AD. In this study, we investigated the whole-brain resting state functional connectivity (FC) of the subjects with preclinical Alzheimer's disease (PAD), mild cognitive impairment due to AD (MCI) and mild dementia due to Alzheimer's disease (AD), the impact of APOE4 carriership, as well as in relation to variations in core AD CSF biomarkers. The synchronization in the whole-brain was monotonously decreasing during the course of the disease progression. Furthermore, in AD patients we found widespread significant decreases in functional connectivity (FC) strengths particularly in the brain regions with high global connectivity. We employed a whole-brain computational modeling approach to study the mechanisms underlying these alterations. To characterize the causal interactions between brain regions, we estimated the effective connectivity (EC) in the model. We found that the significant EC differences in AD were primarily located in left temporal lobe. Then, we systematically manipulated the underlying dynamics of the model to investigate simulated changes in FC based on the healthy control subjects. Furthermore, we found distinct patterns involving CSF biomarkers of amyloid-beta (Aβ1 − 42) total tau (t-tau) and phosphorylated tau (p-tau). CSF Aβ1 − 42 was associated to the contrast between healthy control subjects and clinical groups. Nevertheless, tau CSF biomarkers were associated to the variability in whole-brain synchronization and sensory integration regions. These associations were robust across clinical groups, unlike the associations that were found for CSF Aβ1 − 42. APOE4 carriership showed no significant correlations with the connectivity measures.

資料詳細

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言語: eng - English
 日付: 2017-07-222017-03-242017-08-072017-08-08
 出版の状態: オンラインで出版済み
 ページ: -
 出版情報: -
 目次: -
 査読: 査読あり
 識別子（DOI, ISBNなど）: DOI: 10.1016/j.nicl.2017.08.006
その他: eCollection 2017
PMID: 28861336
PMC: PMC5568172
 学位: -

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Project information

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Project name : The Dynamical and Structural Basis of Human Mind Complexity: Segregation and Integration of Information and Processing in the Brain / DYSTRUCTURE
Grant ID : 295129
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : Spanish National Project Complexity of Brain States
Grant ID : PSI2016-75688-P
Funding program : -
Funding organization : Spanish Research Agency (AEI) and the European Regional Development Fund (ERDF)
Project name : Human Brain Project Specific Grant Agreement 1 / HBP SGA1
Grant ID : 720270
Funding program : Horizon 2020
Funding organization : European Commission (EC)

出版物 1

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出版物名: NeuroImage: Clinical
種別: 学術雑誌
 著者・編者:
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出版社, 出版地: Elsevier
ページ: - 巻号: 16 通巻号: - 開始・終了ページ: 343 - 354 識別子（ISBN, ISSN, DOIなど）: ISSN: 2213-1582
CoNE: https://pure.mpg.de/cone/journals/resource/2213-1582