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  Relationships between structure, in vivo function and long-range axonal target of cortical pyramidal tract neurons

Rojas-Piloni, G., Guest, J. M., Egger, R., Johnson, A. S., Sakmann, B., & Oberlaender, M. (2017). Relationships between structure, in vivo function and long-range axonal target of cortical pyramidal tract neurons. Nature Communications, 8: 870. doi:10.1038/s41467-017-00971-0.

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Rojas-Piloni, G., Author
Guest, Jason Mike1, 2, Author           
Egger, R., Author
Johnson, A. S., Author
Sakmann, B., Author
Oberlaender, Marcel1, Author           
Affiliations:
1Max Planck Research Group In Silico Brain Sciences, Center of Advanced European Studies and Research (caesar), Max Planck Society, ou_2333691              
2International Max Planck Research School (IMPRS) for Brain and Behavior, Max Planck Institute for Neurobiology of Behavior – caesar, Max Planck Society, ou_3481421              

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 Abstract: Pyramidal tract neurons (PTs) represent the major output cell type of the neocortex. To investigate principles of how the results of cortical processing are broadcasted to different downstream targets thus requires experimental approaches, which provide access to the in vivo electrophysiology of PTs, whose subcortical target regions are identified. On the example of rat barrel cortex (vS1), we illustrate that retrograde tracer injections into multiple subcortical structures allow identifying the long-range axonal targets of individual in vivo recorded PTs. Here we report that soma depth and dendritic path lengths within each cortical layer of vS1, as well as spiking patterns during both periods of ongoing activity and during sensory stimulation, reflect the respective subcortical target regions of PTs. We show that these cellular properties result in a structure–function parameter space that allows predicting a PT’s subcortical target region, without the need to inject multiple retrograde tracers.

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Language(s): eng - English
 Dates: 2017-10-11
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-017-00971-0
PMID: 29021587
 Degree: -

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Title: Nature Communications
  Abbreviation : Nat Commun
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 8 Sequence Number: 870 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723